NCT06040541RecruitingPhase 1
Study of RMC-9805 in Participants With KRAS G12D-Mutant Solid Tumors
Phase 1/1b, Multicenter, Open-Label, Study of RMC 9805 in Participants With Advanced KRASG 12D-Mutant Solid Tumors
Source: ClinicalTrials.gov · Last updated 3 Jun 2026
Brief summary (registry, in English)
This study is to evaluate the safety and tolerability of RMC-9805 as monotherapy and in combination with RMC-6236 in adults with KRAS G12D-mutant solid tumors.
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 1
- Study type
- Interventional
- Enrollment
- 604 (estimated)
- First submitted
- 31 Aug 2023
- Start date
- 7 Sept 2023
- Primary completion date
- 31 Dec 2026
- Lead sponsor
- Revolution Medicines, Inc.
- Diseases
- Lung cancer, Pancreatic cancer, Colorectal cancer
- NCT number
- NCT06040541
What you commit to
- Study type: Interventional · Phase 1
- Planned participants: 604
- From 7 Sept 2023 to the primary completion date, 31 Dec 2026
- 17 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Participant was previously treated with an investigational KRAS G12D inhibitor, pan- or multi-RAS inhibitor, or had prior therapy with any direct RAS-targeted therapy (eg, degraders and inhibitors)
- Other inclusion/exclusion criteria may apply.
Other illness
- Known or suspected impairment of gastrointestinal function that may prohibit ability to swallow or absorb an oral medication
Other
- Primary central nervous system (CNS) tumors
- Known or suspected leptomeningeal or active brain metastases or spinal cord compression
Who the study is looking for
- Pathologically documented, locally advanced or metastatic solid tumor with a KRAS G12D-mutation
- Received and progressed or been intolerant to prior standard therapy (including targeted therapy) appropriate for tumor type and stage
- ECOG performance status 0 or 1
- Adequate organ function
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (17)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Johns Hopkins University Coordinator of this site? Confirm its status | Baltimore | United States | Recruiting |
| Massachusetts General Hospital Coordinator of this site? Confirm its status | Boston | United States | Recruiting |
| Dana-Farber Cancer Institute Coordinator of this site? Confirm its status | Boston | United States | Recruiting |
| The Christ Hospital Coordinator of this site? Confirm its status | Cincinnati | United States | Recruiting |
| Sarah Cannon Research Institute at Mary Crowley Coordinator of this site? Confirm its status | Dallas | United States | Recruiting |
| Duke Cancer Center Coordinator of this site? Confirm its status | Durham | United States | Recruiting |
| NEXT Oncology- Virginia Coordinator of this site? Confirm its status | Fairfax | United States | Recruiting |
| University of Texas - MD Anderson Cancer Center Coordinator of this site? Confirm its status | Houston | United States | Recruiting |
| Carolina Biooncology Institute Coordinator of this site? Confirm its status | Huntersville | United States | Recruiting |
| Sarah Cannon Research Institute Coordinator of this site? Confirm its status | Nashville | United States | Recruiting |
| Smilow Cancer Hospital (Yale University) Coordinator of this site? Confirm its status | New Haven | United States | Recruiting |
| NYU Langone Coordinator of this site? Confirm its status | New York | United States | Recruiting |
| Memorial Sloan-Kettering Cancer Center Coordinator of this site? Confirm its status | New York | United States | Recruiting |
| University of California Davis Comprehensive Cancer Center Coordinator of this site? Confirm its status | Sacramento | United States | Recruiting |
| START Coordinator of this site? Confirm its status | San Antonio | United States | Recruiting |
| Florida Cancer Specialists Coordinator of this site? Confirm its status | Sarasota | United States | Recruiting |
| Lee Moffitt Cancer Center Coordinator of this site? Confirm its status | Tampa | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.