NCT06041386Active, not recruitingPhase 4
REIMAGINE – Real-world EvaluatIon of Mepolizumab in severe Asthma achievinG on treatment clinIcal remissioN, a prospEctive study.
A prospective, real-world, interventional study to evaluate the effect of mepolizumab on achieving clinical remission in participants with severe asthma.
Source: EU CTIS (euclinicaltrials.eu) · Last updated 10 Dec 2025
Brief summary (registry, in English)
1. Describe the proportion of patients that achieved clinical remission at 12 months, in the principal stratum of patients’ adherent to NUCALA
- Status (registry)
- Active, not recruiting
- Phase (registry)
- Phase 4
- Study type
- Interventional
- Enrollment
- 170 (estimated)
- First submitted
- 24 Jan 2024
- Start date
- 3 Jun 2024
- Lead sponsor
- Glaxosmithkline Research & Development Limited
- Diseases
- Asthma
- NCT number
- NCT06041386
- EU CT number
- 2023-509026-21-00
What you commit to
- Study type: Interventional · Phase 4
- Planned participants: 170
- 29 sites in 6 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of EU CTIS (euclinicaltrials.eu). It describes the study, not your situation.
Who cannot take part
Copied verbatim from EU CTIS (euclinicaltrials.eu) and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Any NUCALA use in the 6 months prior to enrollment.
- Participants currently on maintenance oral corticosteroids (mOCS) or intramuscular corticosteroids.
- Participants using omalizumab, reslizumab, dupilumab, tezepelumab, or benralizumab within the 6 months prior to enrollment.
Other illness
- Other clinically significant respiratory conditions (e.g., bronchiectasis, pulmonary fibrosis).
Other
- Investigator concerns about participant’s willingness to adhere to biologic treatment for any reason (e.g., cost, behavior, difficulty with access to healthcare)
- Participating in an interventional study with a treatment intervention.
- Current smokers.
Who the study is looking for
- Adults aged 18 years or over
- Participant has a confirmed asthma diagnosis with physician decision to initiate treatment with NUCALA
- Participants with ≥60% predicted FEV1 and ≤4 exacerbations per year, as confirmed by the physician.
- Written informed consent.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (29)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Algemeen Ziekenhuis Groeninge Coordinator of this site? Confirm its status | Kortrijk | Belgium | Active, not recruiting |
| Centre Hospitalier Universitaire de Liège Coordinator of this site? Confirm its status | Liège | Belgium | Active, not recruiting |
| Universitaetsklinikum Aachen AöR Coordinator of this site? Confirm its status | Aachen | Germany | Active, not recruiting |
| Pneumologie, Allergologie Praxis Dr. Thomas Ginko Coordinator of this site? Confirm its status | Bonn | Germany | Active, not recruiting |
| Lungenpraxis Bonn Coordinator of this site? Confirm its status | Bonn | Germany | Active, not recruiting |
| Pneumo Studien Darmstadt GmbH Coordinator of this site? Confirm its status | Darmstadt | Germany | Active, not recruiting |
| Studienzentrum Dr. Keller Coordinator of this site? Confirm its status | Frankfurt | Germany | Active, not recruiting |
| IKF Pneumologie GmbH & Co. KG Coordinator of this site? Confirm its status | Frankfurt am Main | Germany | Active, not recruiting |
| Praxisgemeinschaft Weinkellerstrasse GbR Coordinator of this site? Confirm its status | Hohenstein-Ernstthal | Germany | Active, not recruiting |
| Hospital de la Santa Creu i Sant Pau Coordinator of this site? Confirm its status | Barcelona | Spain | Active, not recruiting |
| Pectus Respiratory Health S.L. Coordinator of this site? Confirm its status | Barcelona | Spain | Active, not recruiting |
| Hospital Arnau de Vilanova de Valencia Coordinator of this site? Confirm its status | Valencia | Spain | Active, not recruiting |
| Centre Hospitalier Regional Et Universitaire De Brest Coordinator of this site? Confirm its status | Brest Cedex 2 | France | Active, not recruiting |
| Centre Hospitalier De Cannes Simone Veil Coordinator of this site? Confirm its status | Cannes Cedex | France | Active, not recruiting |
| Centre Hospitalier Universitaire de Lille Coordinator of this site? Confirm its status | Lille | France | Active, not recruiting |
| Hospices Civils De Lyon Coordinator of this site? Confirm its status | Lyon Cedex 04 | France | Active, not recruiting |
| Les Hopitaux Universitaires De Strasbourg Coordinator of this site? Confirm its status | Strasbourg Cedex | France | Active, not recruiting |
| Centre Hospitalier Universitaire De Toulouse Coordinator of this site? Confirm its status | Toulouse Cedex 9 | France | Active, not recruiting |
| Azienda Ospedaliero - Universitaria di Cagliari Coordinator of this site? Confirm its status | Cagliari | Italy | Active, not recruiting |
| IRCCS Ospedale Policlinico San Martino Coordinator of this site? Confirm its status | Genoa | Italy | Active, not recruiting |
| Azienda Ospedaliera dei Colli Coordinator of this site? Confirm its status | Naples | Italy | Active, not recruiting |
| Fondazione Policlinico Universitario Campus Bio-Medico Coordinator of this site? Confirm its status | Rome | Italy | Active, not recruiting |
| Fondazione Policlinico Universitario Agostino Gemelli IRCCS Coordinator of this site? Confirm its status | Rome | Italy | Active, not recruiting |
| Humanitas Research Hospital Coordinator of this site? Confirm its status | Rozzano | Italy | Active, not recruiting |
| Azienda Unita' Locale Socio Sanitaria N. 2 Marca Trevigiana Coordinator of this site? Confirm its status | Treviso | Italy | Active, not recruiting |
| Centro Ricerche Cliniche di Verona s.r.l. Coordinator of this site? Confirm its status | Verona | Italy | Active, not recruiting |
| Uniwersyteckie Centrum Kliniczne Coordinator of this site? Confirm its status | Gdansk | Poland | Active, not recruiting |
| Samodzielny Publiczny Zaklad Opieki Zdrowotnej Uniwersytecki Szpital Kliniczny Nr 1 Im. Norberta Barlickiego Uniwersytetu Medycznego W Lodzi Coordinator of this site? Confirm its status | Lodz | Poland | Active, not recruiting |
| Samodzielny Publiczny Zaklad Opieki Zdrowotnej Centralny Szpital Kliniczny Uniwersytetu Medycznego W Lodzi Coordinator of this site? Confirm its status | Lodz | Poland | Active, not recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.