NCT06042244Completed
Multimodal Exercise Training to Reduce Frailty in People With Multiple Sclerosis
Source: ClinicalTrials.gov · Last updated 15 Jun 2025
Brief summary (registry, in English)
Study Significance: This proposed investigation is designed to examine the feasibility of an exercise-based intervention to reduce frailty in people living with MS. The proposed research will be the first to establish the feasibility of targeting frailty in pwMS and will begin to examine the dynamic nature of frailty in MS. These advances will pave the way for planned prospective studies toward effective targets for diagnostics, and rehabilitation of frailty in MS.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 16 (actual)
- First submitted
- 21 Jul 2023
- Start date
- 20 Nov 2023
- Primary completion date
- 23 Feb 2025
- Lead sponsor
- University of Kansas Medical Center
- Diseases
- Multiple sclerosis
- NCT number
- NCT06042244
What you commit to
- Study type: Interventional
- Participants enrolled: 16
- From 20 Nov 2023 to the primary completion date, 23 Feb 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- are diagnosed with other clinically important neurological conditions (such as Parkinson's Disease, epilepsy, etc.)
- exhibit severe cognitive impairment (as determined by a Mini-Cog score \<3)
- are diagnosed with active psychiatric problems.
- unstable cardiovascular conditions (e.g., malignant arrhythmias, critical mitral stenosis, clinically severe left ventricular outflow obstruction, critical proximal coronary artery stenosis)
Other
- unable to walk unassisted for at least ten meters
- arthritis of the lower limbs
- acute lower back or lower limbs pain
- rheumatic and/or severe orthopedic problems that may interfere with resistance training.
Who the study is looking for
- Subjects must be aged 40-65 years old to be enrolled in this study.
- Subjects must meet 3 of 5 frailty criteria (weight loss; exhaustion; weakness; slowness; inactivity) to be considered.
- Subjects must have a confirmed diagnosis of MS by the treating neurologist
- be free from MS relapses in the last 30 days
- have an Expanded Disability Status Scale (EDSS) score ≤ 6.0
- be fluent in spoken and written English.
Age in the registry: 40 years to 65 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Landon Center On Aging Coordinator of this site? Confirm its status | Kansas City | United States | Unknown status |
Related publications
- Reducing frailty in frail people with multiple sclerosis: Feasibility of a 6-week multimodal exercise training program.PLoS One · 2026 · PMID 41984883
This page is information, not medical advice. Discuss any trial with your doctor.