NCT06043401Active, not recruiting
Tracking Brain Biomarkers and Renormalization Associated With Antidepressant Transcranial Magnetic Stimulation Therapy
Source: ClinicalTrials.gov · Last updated 20 Apr 2026
Brief summary (registry, in English)
This study will attempt to use magnetic resonance imaging (MRI) to take a picture of the brain to learn about changes that occur in the brain during Transcranial Magnetic Stimulation (TMS) in people receiving this treatment for depression.
- Status (registry)
- Active, not recruiting
- Study type
- Observational
- Enrollment
- 40 (estimated)
- First submitted
- 16 Aug 2023
- Start date
- 4 Apr 2023
- Primary completion date
- 1 Apr 2027
- Lead sponsor
- Medical University of South Carolina
- Diseases
- Depression
- NCT number
- NCT06043401
What you commit to
- Study type: Observational
- Planned participants: 40
- From 4 Apr 2023 to the primary completion date, 1 Apr 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Any current or recent untreated medical, neurological, or psychiatric conditions other than MDD that would preclude candidacy for TMS.
- Metal implant devices in the head, heart, or neck.
- History of brain surgery.
- History of cortisol medication use or electroconvulsive therapy.
- History of myocardial infarction or arrhythmia, bradycardia.
- Personal history of recent head injury, concussion, or self-report of moderate to severe traumatic brain injury.
- Moderate to severe alcohol or substance use disorder.
- Any current or recent untreated medical, neurological, or psychiatric conditions
- Metal implant devices in the head, heart, or neck.
- History of brain surgery.
- History of cortisol medication use or electroconvulsive therapy.
- Comorbidity with other psychiatric/neurological illnesses or personality disorders
- History of myocardial infarction or arrhythmia, bradycardia.
- Personal history of recent head injury, concussion, or self-report of moderate to severe traumatic brain injury.
- Moderate to severe alcohol or substance use disorder.
Age
- Age 18-65
Other
- Unable to speak English.
- Contraindicated for MRI.
- Individuals suffering from frequent/severe headaches.
- Pregnancy
- Healthy Volunteers Inclusion Criteria
- Have the capacity and ability to provide one's own consent in English and sign the informed consent document.
- Unable to speak English.
- Contraindicated for MRI.
- Individuals suffering from frequent/severe headaches.
- Pregnancy
Who the study is looking for
- Age 18-65
- Have the capacity and ability to provide one's own consent in English and sign the informed consent document.
- DSM-IV diagnosis of MDD
Criteria the registry did not label
- MDD volunteers:
Age in the registry: 18 years to 65 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Medical University of South Carolina Coordinator of this site? Confirm its status | Charleston | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.