NCT06044051Recruiting
Dynamics of the Upper and Lower Airway Respiratory Microbiomes Associated With Severe Infant Asthma
Dynamique Des Microbiomes Respiratoires Des Voies supérieures et inférieures associée à l'Asthme sévère Des Nourrissons
Source: ClinicalTrials.gov · Last updated 17 Feb 2026
Brief summary (registry, in English)
Nature of potential dysbiosis, interrelation of the different microbiomes of the respiratory tract, and potential role of the immune system in the pathogenesis of severe asthma in infants, and its evolution under treatment. Exploring and understanding these data is to improve patient care and discover new therapeutic targets. The aim is to open up prospects for therapeutic studies, such as the use of azithromycin as an immunomodulator in infant asthma, the results of which are discordant.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 100 (estimated)
- First submitted
- 27 Jul 2023
- Start date
- 26 Sept 2023
- Primary completion date
- 26 Sept 2026
- Lead sponsor
- University Hospital, Rouen
- Diseases
- Asthma
- NCT number
- NCT06044051
What you commit to
- Study type: Interventional
- Planned participants: 100
- From 26 Sept 2023 to the primary completion date, 26 Sept 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Antibiotic therapy in progress or administered the seven days preceding the date of inclusion (day hospitalization)
Other illness
- Congenital heart disease with significant left to right shunt
- Chronic respiratory disease other than infant asthma (cystic fibrosis, bronchiolitis obliterans)
Other
- Prematurity \<32 WA
- Refusal of bronchial fibroscopy
Who the study is looking for
- Infants less than 24 months old
- Follow-up by a pneumo-pediatrician for severe asthma in infants
- Requiring etiological investigations and assessment of severity in day hospitalization, including bronchial fibroscopy (HAS 2009)
- Parent informed of the research and having signed consent
Age in the registry: - to 24 months · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Rouen University Hospital Coordinator of this site? Confirm its status | Rouen | France | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.