NCT06045702Recruiting
Establishment of a Primary Epididymal Cell Model From Epididymal Samples to Study CFTR Gene Regulation
Source: ClinicalTrials.gov · Last updated 20 Mar 2026
Brief summary (registry, in English)
The aim of this observational study is to better understand the role and involvement of the regulatory elements of the CFTR gene, with the aim of better describing the 3D organisation of chromatin at the CFTR locus in epididymal cells in patients with male infertility of any kind, or with cystic fibrosis or bilateral agenesis of the vas deferens, requiring scheduled surgery. The main questions it aims to answer are: * to better characterise this 3D organisation of the CFTR locus, the study of regulatory elements in primary epididymal cells is the most relevant and realistic model. * to gain a better understanding of the regulation of the CFTR gene in epididymal cells in order to gain a better understanding of the pathology of male infertility caused by bilateral agenesis of the vas deferens, a symptom and also a borderline form of cystic fibrosis. Participants will Epididymal samples will be taken by a urologist for the AMP department during the planned surgery. The rest of the samples taken will be recovered for research purposes, with the aim of recovering the epididymal cells contained in the sample. This is in no way an additional procedure and will have no impact on the patient's health..
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 20 (estimated)
- First submitted
- 14 Sept 2023
- Start date
- Sept 2024
- Primary completion date
- Sept 2026
- Lead sponsor
- University Hospital, Brest
- Diseases
- Cystic fibrosis
- NCT number
- NCT06045702
What you commit to
- Study type: Observational
- Planned participants: 20
- From Sept 2024 to the primary completion date, Sept 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Patients not scheduled for epididymal harvesting surgery
Other
- Patients under legal protection (guardianship, curatorship)
- Refusal to participate
Who the study is looking for
- Male patients over 18 years of age
- Patients, without genetic pathology, scheduled for epididymal sampling surgery
- Patients with cystic fibrosis or bilateral vas deferens agenesis, scheduled for epididymal sampling surgery.
- Signature of a consent form
Age in the registry: 18 years to - · Sex: Male · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Antoine VALERI Coordinator of this site? Confirm its status | Brest | France | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.