NCT06047717Recruiting
Vision Loss Impact on Navigation in Virtual Reality
The Impact of Vision Loss on Naturalistic Behavior and Navigation in Virtual Reality
Source: ClinicalTrials.gov · Last updated 25 Aug 2026
Brief summary (registry, in English)
The purpose of this research is to better understand the impact of cortically-induced blindness (CB) and the compensatory strategies subjects with this condition may develop on naturalistic behaviors, specifically, driving. Using a novel Virtual Reality (VR) program, the researchers will gather data on steering behavior in a variety of simulated naturalistic environments. Through the combined use of computer vision, deep learning, and gaze-contingent manipulations of the visual field, this work will test the central hypothesis that changes to visually guided steering behaviors in CB are a consequence of changes to the visual sampling and processing of task-related motion information (i.e., optic flow).
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 40 (estimated)
- First submitted
- 8 Sept 2023
- Start date
- 28 Nov 2023
- Primary completion date
- Oct 2028
- Lead sponsor
- University of Rochester
- Diseases
- Stroke
- NCT number
- NCT06047717
What you commit to
- Study type: Interventional
- Planned participants: 40
- From 28 Nov 2023 to the primary completion date, Oct 2028
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Past or present ocular disease interfering with visual acuity
- History of traumatic brain injury
- Documented history of drug/alcohol abuse
- Diagnosis of cognitive or seizure disorders
- Presence of vision loss from ocular diseases or disorders
- Subjects with a history of neurological disorders
- Subjects with a history of TBI
Other
- Those who have never driven or earned a drivers' license
- Best corrected visual acuity (BCVA) worse than 20/40 in either eye
- Sustained damage to the dorsal lateral geniculate nucleus
- Presence of diffuse, whole-brain degenerative processes
- Presence of brain damage deemed by study staff to potentially interfere with outcome measures
- Diagnosis of one-sided attentional neglect
- Control Group:
- Subjects who have never driven or earned a drivers' license
- BCVA worse than 20/40 in either eye
- Presence of a visual field defect
- Inability to wear corrective contact lenses inside the virtual reality helmet if required to see clearly
- Persons who lack the competence or are otherwise unable to perform the visual testing as directed.
Who the study is looking for
- Residents of the United States or Canada
- Presence of one-sided stroke or stroke-like damage to primary visual cortex or its immediate afferent white matter sustained within the specified age range of 21 - 75 years (verified by MRI and/or CT scans)
- Reliable visual field defects in both eyes (homonymous defects) as measured by Humphrey or equivalent perimetry.
- Willing, able, and competent to provide their own informed consent
- Cognitively able, responsible to understand written and oral instructions in English
- Emmetropic or else wear corrective contact lenses inside the virtual reality headset
- Normal or corrected-to-normal vision, who are between the ages of 21 and 75 years of age, roughly matched to the age of CB subjects enrolled above
- Competent and responsible, as determined by the Principal Investigator
- Willing, able, and competent to provide their own informed consent
- Normal cognitive abilities, be able to understand written and oral instructions in English
- Emmetropic or else wear corrective contact lenses inside the virtual reality headset
Criteria the registry did not label
- Cortically Blind Group:
Age in the registry: 21 years to 75 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Rochester Coordinator of this site? Confirm its status | Rochester | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.