NCT06048055Completed
Effect of Transcutaneous Vagus Nerve Stimulation on Upper Limb Function in Stroke Patients
Efficacy of Non Invasive Vagus Nerve Stimulation on Motor Function of Upper Extremity in Chronic Stroke Patients
Source: ClinicalTrials.gov · Last updated 30 Apr 2025
Brief summary (registry, in English)
The goal of this interventional study is to investigate the therapeutic efficacy of non-invasive vagus nerve stimulation on upper limb function in chronic stroke patients . The main question is: •Is there a significant effect of non-invasive vagal nerve stimulation on upper limb motor function in stroke patients? Participants will be assigned into two groups. They will receive 12 sessions of true or sham transcutaneous auricular vagus nerve stimulation for 30 minutes immediately followed by 30 minutes of selected physical therapy program, three sessions per week for four weeks.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 40 (actual)
- First submitted
- 12 Sept 2023
- Start date
- 1 Oct 2023
- Primary completion date
- 3 Apr 2024
- Lead sponsor
- Cairo University
- Diseases
- Stroke
- NCT number
- NCT06048055
What you commit to
- Study type: Interventional
- Participants enrolled: 40
- From 1 Oct 2023 to the primary completion date, 3 Apr 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Patients with previous surgical intervention on the vagus nerve.
Other illness
- Patients with neurological diseases that affect upper limb function other than stroke (e.g.: Multiple sclerosis, Peripheral neuropathy, Parkinsonism….etc.).
- Hemorrhagic stroke patients.
- Patients with a history of significant alcohol or drug abuse.
- Patients with musculoskeletal disorders such as severe arthritis, knee surgery, total hip joint replacement, lower limb fractures or contractures of fixed deformity, and leg length discrepancy after total hip replacement.
- Patients with cardiovascular problems (unstable angina, recent myocardial infarction, congestive heart failure, significant heart valve dysfunction, or unstable hypertension) or pulmonary or kidney disorders.
- Patients with visual or auditory impairment affecting their ability to complete the testing.
- Patients with cognitive impairment.
- Any current or past history of facial or ear pain, recent ear trauma, or metal implants above the level of the neck.
Other
- Patients with pacemakers or other implanted electrical devices.
Who the study is looking for
- Hemiparetic patients with ischemic middle cerebral artery stroke.
- Duration of illness ranged from at least 6 months after stroke.
- The patient's age ranged from 45 to 65 years.
- Spasticity of upper limb muscles ranged from (grade 1:2) according to the Modified Ashworth scale.
- The patients with unilateral upper limb motor function impairment.
- Patients with sufficient cognitive abilities that enable them to understand and follow instructions.
Age in the registry: 45 years to 65 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Faculty of physical therapy labs at Cairo University Coordinator of this site? Confirm its status | Giza | Egypt | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.