NCT06049017CompletedPhase 2
A Study of JNJ-77242113 in Participants With Moderately to Severely Active Ulcerative Colitis
A Phase 2b Multicenter, Randomized, Placebo- Controlled, Dose-Ranging Study to Evaluate the Efficacy and Safety of JNJ-77242113 for the Treatment of Moderately to Severely Active Ulcerative Colitis
Source: ClinicalTrials.gov · Last updated 13 Apr 2026
Brief summary (registry, in English)
The purpose of this study is to evaluate the safety and effectiveness of JNJ-77242113 compared with placebo in participants with moderately to severely active ulcerative colitis.
- Status (registry)
- Completed
- Phase (registry)
- Phase 2
- Study type
- Interventional
- Enrollment
- 252 (actual)
- First submitted
- 15 Sept 2023
- Start date
- 9 Oct 2023
- Primary completion date
- 26 Sept 2024
- Lead sponsor
- Janssen Research & Development, LLC
- Diseases
- Ulcerative colitis
- NCT number
- NCT06049017
- EU CT number
- 2023-504673-20-00
What you commit to
- Study type: Interventional · Phase 2
- Participants enrolled: 252
- From 9 Oct 2023 to the primary completion date, 26 Sept 2024
- 178 sites in 21 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Participants with current or prior diagnosis of fulminant colitis and/or toxic megacolon
Other illness
- Presence or history of fistula
- History of extensive colonic resection (example, \<30 cm of colon remaining)
- Diagnosis of indeterminate colitis, microscopic colitis, ischemic colitis, Crohn's colitis or clinical findings suggestive of Crohn's disease
Other
- UC limited to rectum only or to less than (\<) 15 centimeters (cm) of colon
- Presence of a stoma
Who the study is looking for
- Signed informed consent form 18 years of age or older
- Documented diagnosis of ulcerative colitis (UC) of at least 12 weeks prior to screening
- Moderately to severely active UC as per the modified Mayo score
- Demonstrated inadequate response to or intolerance of conventional therapy and/or advanced therapy as defined in the protocol
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (178)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| CIPREC Coordinator of this site? Confirm its status | Buenos Aires | Argentina | Unknown status |
| Gedyt - Consultorios Gastroenterologia Coordinator of this site? Confirm its status | Buenos Aires | Argentina | Unknown status |
| Cer Instituto Medico Coordinator of this site? Confirm its status | Buenos Aires | Argentina | Unknown status |
| Hospital Provincial del Centenario Coordinator of this site? Confirm its status | Rosario | Argentina | Unknown status |
| Sanatorio 9 de Julio Coordinator of this site? Confirm its status | San Miguel de Tucumán | Argentina | Unknown status |
| Sunshine Coast University Hospital Coordinator of this site? Confirm its status | Birtinya | Australia | Unknown status |
| Blacktown Hospital Coordinator of this site? Confirm its status | Blacktown | Australia | Unknown status |
| Concord Repatriation General Hospital Coordinator of this site? Confirm its status | Concord | Australia | Unknown status |
| Wollongong Private Hospital Coordinator of this site? Confirm its status | Wollongong | Australia | Unknown status |
| CHU Saint-Pierre Coordinator of this site? Confirm its status | Brussels | Belgium | Completed |
| Universitair Ziekenhuis Gent Coordinator of this site? Confirm its status | Gent | Belgium | Completed |
| AZ Sint-Lucas & Volkskliniek Coordinator of this site? Confirm its status | Gent | Belgium | Completed |
| UZ Leuven Coordinator of this site? Confirm its status | Leuven | Belgium | Completed |
| CHU de Liège Coordinator of this site? Confirm its status | Liège | Belgium | Completed |
| Vitaz Coordinator of this site? Confirm its status | Sint-Niklaas | Belgium | Completed |
| Unesp - Faculdade de Medicina Da Universidade Estadual Paulista - Campus Botucatu Coordinator of this site? Confirm its status | Botucatu | Brazil | Unknown status |
| L2IP - Instituto de Pesquisas Clínicas Coordinator of this site? Confirm its status | Brasília | Brazil | Unknown status |
| CDC - Centro Digestivo de Curitiba Coordinator of this site? Confirm its status | Curitiba | Brazil | Unknown status |
| Hospital de Clinicas de Porto Alegre - Hospital de Clinicas Coordinator of this site? Confirm its status | Porto Alegre | Brazil | Unknown status |
| Pesquisare Saude Coordinator of this site? Confirm its status | Santo André | Brazil | Unknown status |
| BR Trials - Ensaios Clínicos e Consultoria Ltda. Coordinator of this site? Confirm its status | São Paulo | Brazil | Unknown status |
| Instituto D'or de Pesquisa e Ensino Coordinator of this site? Confirm its status | São Paulo | Brazil | Unknown status |
| Integral Pesquisa e Ensino Coordinator of this site? Confirm its status | Votuporanga | Brazil | Unknown status |
| Barrie GI Associates Coordinator of this site? Confirm its status | Barrie | Canada | Unknown status |
| Gastroenterology and Internal Medicine Research Institute (GIRI) Coordinator of this site? Confirm its status | Edmonton | Canada | Unknown status |
| London Health Sciences Centre Coordinator of this site? Confirm its status | London | Canada | Unknown status |
| Centre Hospitalier de l'Université de Montréal Coordinator of this site? Confirm its status | Montreal | Canada | Unknown status |
| ABP Research Services Corp. Coordinator of this site? Confirm its status | Oakville | Canada | Unknown status |
| The Second Xiangya Hospital of Central South University Coordinator of this site? Confirm its status | Changsha | China | Unknown status |
| Chongqing General Hospital Coordinator of this site? Confirm its status | Chongqing | China | Unknown status |
| The Sixth Affiliated Hospital, Sun Yat-sen University Coordinator of this site? Confirm its status | Guangzhou | China | Unknown status |
| The First Affiliated Hospital, Sun Yat-sen University Coordinator of this site? Confirm its status | Guangzhou | China | Unknown status |
| Sir Run Run Shaw Hospital Zhejiang University School of Medicine Coordinator of this site? Confirm its status | Hangzhou | China | Unknown status |
| Qilu Hospital of Shandong University Coordinator of this site? Confirm its status | Jinan | China | Unknown status |
| Lanzhou University Second Hospital Coordinator of this site? Confirm its status | Lanzhou | China | Unknown status |
| Nanjing Drum Tower hospital Coordinator of this site? Confirm its status | Nanjing | China | Unknown status |
| Shengjing Hospital Of China Medical University Coordinator of this site? Confirm its status | Shenyang | China | Unknown status |
| Union Hospital Tongji Medical College of Huazhong University of Science and Technology Coordinator of this site? Confirm its status | Wuhan | China | Unknown status |
| Wuxi People's Hospital Coordinator of this site? Confirm its status | Wuxi | China | Unknown status |
| The Second Affiliated Hospital of Air Force Medical University - Tangdu Hospital Coordinator of this site? Confirm its status | Xi'an | China | Unknown status |
| Nemocnice České Budějovice, a.s. Coordinator of this site? Confirm its status | České Budějovice | Czechia | Completed |
| Hepato-Gastroenterologie HK, s.r.o. Coordinator of this site? Confirm its status | Hradec Králové | Czechia | Completed |
| Gastroenterologie s.r.o. Coordinator of this site? Confirm its status | Hradec Králové | Czechia | Completed |
| ISCARE a.s. Coordinator of this site? Confirm its status | Prague | Czechia | Completed |
| Nemocnice Slany Coordinator of this site? Confirm its status | Slaný | Czechia | Completed |
| Universitaetsklinikum Augsburg Coordinator of this site? Confirm its status | Augsburg | Germany | Completed |
| Krankenhaus Waldfriede e.V. Coordinator of this site? Confirm its status | Berlin | Germany | Completed |
| Technische Universität Dresden Coordinator of this site? Confirm its status | Dresden | Germany | Completed |
| Medizinische Hochschule Hannover Coordinator of this site? Confirm its status | Hanover | Germany | Completed |
| Universitaetsklinikum Schleswig-Holstein Coordinator of this site? Confirm its status | Kiel | Germany | Completed |
| Eugastro GmbH Coordinator of this site? Confirm its status | Leipzig | Germany | Completed |
| Staedtisches Klinikum Lueneburg gGmbH Coordinator of this site? Confirm its status | Lueneburg | Germany | Completed |
| Gastroenterologische Gemeinschaftspraxis Minden Coordinator of this site? Confirm its status | Minden | Germany | Completed |
| Area Sanitaria De Ferrol Coordinator of this site? Confirm its status | Ferrol | Spain | Completed |
| Hospital Universitario de Cabueñes Coordinator of this site? Confirm its status | Gijón | Spain | Completed |
| Hospital Universitario La Paz Coordinator of this site? Confirm its status | Madrid | Spain | Completed |
| Hospital Universitario Fundacion Alcorcon Coordinator of this site? Confirm its status | Madrid | Spain | Completed |
| Hospital Universitario Puerta de Hierro de Majadahonda Coordinator of this site? Confirm its status | Majadahonda | Spain | Completed |
| Complexo Hospitalario Universitario De Santiago Coordinator of this site? Confirm its status | Santiago de Compostela | Spain | Completed |
| Hospital Universitario Virgen De La Macarena Coordinator of this site? Confirm its status | Sevilla | Spain | Completed |
| Hospital Universitario Virgen De Valme Coordinator of this site? Confirm its status | Sevilla | Spain | Completed |
| Hospital Clinico Universitario de Valencia Coordinator of this site? Confirm its status | Valencia | Spain | Completed |
| Hospital Universitario Y Politecnico La Fe Coordinator of this site? Confirm its status | Valencia | Spain | Completed |
| Complexo Hospitalario Universitario De Vigo Coordinator of this site? Confirm its status | Vigo | Spain | Completed |
| Besancon University Hospital Center Coordinator of this site? Confirm its status | Besancon Cedex | France | Completed |
| Assistance Publique Hopitaux De Paris Coordinator of this site? Confirm its status | Creteil | France | Completed |
| Centre Hospitalier Universitaire De Lille Coordinator of this site? Confirm its status | Lille Cedex | France | Completed |
| Centre Medico Chirurgical Ambroise Pare Hartmann Coordinator of this site? Confirm its status | Neuilly-Sur-Seine | France | Completed |
| Centre Hospitalier Universitaire de Nice Coordinator of this site? Confirm its status | Nice | France | Completed |
| Centre Hospitalier Universitaire De Nimes Coordinator of this site? Confirm its status | Nimes Cedex 9 | France | Completed |
| Assistance Publique Hopitaux De Paris Coordinator of this site? Confirm its status | Paris Cedex 18 | France | Completed |
| Hospices Civils de Lyon Coordinator of this site? Confirm its status | Pierre-Bénite | France | Completed |
| Centre Hospitalier Universitaire de Saint Etienne Coordinator of this site? Confirm its status | Saint-Etienne | France | Completed |
| Centre Hospitalier Universitaire De Toulouse Coordinator of this site? Confirm its status | Toulouse Cedex 9 | France | Completed |
| CHRU De Nancy Coordinator of this site? Confirm its status | Vandoeuvre Les Nancy | France | Completed |
| Fairfield General Hospital Coordinator of this site? Confirm its status | Bury | United Kingdom | Unknown status |
| Addenbrookes Hospital Coordinator of this site? Confirm its status | Cambridge | United Kingdom | Unknown status |
| Barts Health NHS Trust Coordinator of this site? Confirm its status | London | United Kingdom | Unknown status |
| St Georges University Hospital NHS Foundation Trust Coordinator of this site? Confirm its status | London | United Kingdom | Unknown status |
| Guys & St Thomas Hospital Coordinator of this site? Confirm its status | London | United Kingdom | Unknown status |
| Kings College Hospital Coordinator of this site? Confirm its status | London | United Kingdom | Unknown status |
| Oxford University Hospitals NHS Foundation Trust Coordinator of this site? Confirm its status | Oxford | United Kingdom | Unknown status |
| Whiston Hospital Coordinator of this site? Confirm its status | Prescot | United Kingdom | Unknown status |
| Southampton University Hospital Coordinator of this site? Confirm its status | Southampton | United Kingdom | Unknown status |
| Semmelweis University Coordinator of this site? Confirm its status | Budapest VIII | Hungary | Completed |
| Pannonia Maganorvosi Centrum Kft. Coordinator of this site? Confirm its status | Budapest XIII | Hungary | Completed |
| University of Debrecen Coordinator of this site? Confirm its status | Debrecen | Hungary | Completed |
| Vasutegeszseguegyi Nonprofit Koezhasznu Kft. Coordinator of this site? Confirm its status | Debrecen | Hungary | Completed |
| Bugat Pal Korhaz Kht. Coordinator of this site? Confirm its status | Gyongyos | Hungary | Completed |
| S. R. Kalla Memorial General Hospital Coordinator of this site? Confirm its status | Jaipur | India | Unknown status |
| Midas Hospital Coordinator of this site? Confirm its status | Nagpur | India | Unknown status |
| Govind Ballabh Pant Hospital Coordinator of this site? Confirm its status | New Delhi | India | Unknown status |
| SIDS Hospital & Research Centre Coordinator of this site? Confirm its status | Surat | India | Unknown status |
| ARNAS G. Brotzu Coordinator of this site? Confirm its status | Cagliari | Italy | Completed |
| Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico Coordinator of this site? Confirm its status | Milan | Italy | Completed |
| Ospedale San Raffaele S.r.l. Coordinator of this site? Confirm its status | Milan | Italy | Completed |
| IRCCS Ospedale Sacro Cuore Don Calabria Coordinator of this site? Confirm its status | Negrar | Italy | Completed |
| Azienda Ospedale Universita Padova Coordinator of this site? Confirm its status | Padova | Italy | Completed |
| Fondazione Policlinico Universitario Agostino Gemelli IRCCS Coordinator of this site? Confirm its status | Rome | Italy | Completed |
| San Camillo Forlanini Hospital Coordinator of this site? Confirm its status | Rome | Italy | Completed |
| Humanitas Research Hospital Coordinator of this site? Confirm its status | Rozzano | Italy | Completed |
| Casa Sollievo della Sofferenza Coordinator of this site? Confirm its status | San Giovanni Rotondo | Italy | Completed |
| Sai Gastroenterology Proctology Coordinator of this site? Confirm its status | Fujiidera-shi | Japan | Unknown status |
| Hamamatsu University Hospital Coordinator of this site? Confirm its status | Hamamatsu | Japan | Unknown status |
| Kagoshima IBD Gastroenterology Clinic Coordinator of this site? Confirm its status | Kagoshima | Japan | Unknown status |
| Tsujinaka Hospital Kashiwanoha Coordinator of this site? Confirm its status | Kashiwa | Japan | Unknown status |
| Aoyama Naika Clinic Coordinator of this site? Confirm its status | Kobe | Japan | Unknown status |
| Kinshukai Infusion Clinic Coordinator of this site? Confirm its status | Osaka | Japan | Unknown status |
| Japanese Red Cross Osaka Hospital Coordinator of this site? Confirm its status | Osaka | Japan | Unknown status |
| Toho University Sakura Medical Center Coordinator of this site? Confirm its status | Sakura | Japan | Unknown status |
| Sapporo Higashi Tokushukai Hospital Coordinator of this site? Confirm its status | Sapporo | Japan | Unknown status |
| Sapporo Tokushukai Hospital Coordinator of this site? Confirm its status | Sapporo | Japan | Unknown status |
| National Hospital Organization Shizuoka Medical Center Coordinator of this site? Confirm its status | Shimizu | Japan | Unknown status |
| Tokyo Metropolitan Bokutoh Hospital Coordinator of this site? Confirm its status | Sumida-ku | Japan | Unknown status |
| Mie University Hospital Coordinator of this site? Confirm its status | Tsu | Japan | Unknown status |
| Yokohama City University Medical Center Coordinator of this site? Confirm its status | Yokohama | Japan | Unknown status |
| Inje University Haeundae Paik Hospital Coordinator of this site? Confirm its status | Busan | South Korea | Unknown status |
| Yeungnam University Hospital Coordinator of this site? Confirm its status | Daegu | South Korea | Unknown status |
| Asan Medical Center Coordinator of this site? Confirm its status | Seoul | South Korea | Unknown status |
| Kangbuk Samsung Hospital Coordinator of this site? Confirm its status | Seoul | South Korea | Unknown status |
| Samsung Medical Center Coordinator of this site? Confirm its status | Seoul | South Korea | Unknown status |
| Seoul National University Hospital Coordinator of this site? Confirm its status | Seoul | South Korea | Unknown status |
| The Catholic University of Korea St. Vincent's Hospital Coordinator of this site? Confirm its status | Suwon | South Korea | Unknown status |
| Hospital Sultanah Aminah Coordinator of this site? Confirm its status | Johor Bahru | Malaysia | Unknown status |
| Sultan Idris Shah Hospital Coordinator of this site? Confirm its status | Kajang | Malaysia | Unknown status |
| University Malaya Medical Centre Coordinator of this site? Confirm its status | Kuala Lumpur | Malaysia | Unknown status |
| Manermed Sp. z o.o. Coordinator of this site? Confirm its status | Bydgoszcz | Poland | Completed |
| Centrum Medyczne Lukamed Joanna Luka Coordinator of this site? Confirm its status | Chojnice | Poland | Completed |
| Centrum Medyczne Plejady Sp. z o.o. S.K. Coordinator of this site? Confirm its status | Cracow | Poland | Completed |
| Centrum Medyczne Medyk Sp. z o.o. Coordinator of this site? Confirm its status | Rzeszow | Poland | Completed |
| Sonomed Sp. z o.o. Coordinator of this site? Confirm its status | Szczecin | Poland | Completed |
| GASTROMED Sp. z o.o. Coordinator of this site? Confirm its status | Torun | Poland | Completed |
| Bodyclinic sp. z o.o. sp.k. Coordinator of this site? Confirm its status | Warsaw | Poland | Completed |
| Panstwowy Instytut Medyczny Ministerstwa Spraw Wewnetrznych i Administracji Coordinator of this site? Confirm its status | Warsaw | Poland | Completed |
| Medical Network Sp z o o Coordinator of this site? Confirm its status | Warsaw | Poland | Completed |
| Centrum Medyczne Oporow Coordinator of this site? Confirm its status | Wroclaw | Poland | Completed |
| Melita Medical Sp. z o.o. Coordinator of this site? Confirm its status | Wroclaw | Poland | Completed |
| EMC Instytut Medyczny S.A. Coordinator of this site? Confirm its status | Wroclaw | Poland | Completed |
| Delta Health Care S.R.L Coordinator of this site? Confirm its status | Bucharest | Romania | Completed |
| Spitalul De Oncologie Monza S.R.L. Coordinator of this site? Confirm its status | Bucharest | Romania | Completed |
| Tvm Med Serv S.R.L. Coordinator of this site? Confirm its status | Cluj-Napoca | Romania | Completed |
| Valahia Medical S.R.L. Coordinator of this site? Confirm its status | Ploiesti | Romania | Completed |
| Clinnova Research Coordinator of this site? Confirm its status | Anaheim | United States | Unknown status |
| Atlanta Gastroenterology Associates Coordinator of this site? Confirm its status | Atlanta | United States | Unknown status |
| Mercy Medical Center Coordinator of this site? Confirm its status | Baltimore | United States | Unknown status |
| Washington Gastroenterology, PLLC Coordinator of this site? Confirm its status | Bellevue | United States | Unknown status |
| UNC Hospitals Coordinator of this site? Confirm its status | Chapel Hill | United States | Unknown status |
| Atrium Health Coordinator of this site? Confirm its status | Charlotte | United States | Unknown status |
| Charlotte Gastroenterology and Hepatology, PLLC Coordinator of this site? Confirm its status | Charlotte | United States | Unknown status |
| Gastroenterology Associates of Tidewater Coordinator of this site? Confirm its status | Chesapeake | United States | Unknown status |
| Peak Gastroenterology Associates Coordinator of this site? Confirm its status | Colorado Springs | United States | Unknown status |
| DHAT Research Institute Coordinator of this site? Confirm its status | Garland | United States | Unknown status |
| Amel Med LLC Research Coordinator of this site? Confirm its status | Georgetown | United States | Unknown status |
| Gastroenterology Associates P.A. Coordinator of this site? Confirm its status | Greenville | United States | Unknown status |
| Accurate Clinical Research, Inc Coordinator of this site? Confirm its status | Humble | United States | Unknown status |
| Ochsner Medical Center Coordinator of this site? Confirm its status | Jefferson | United States | Unknown status |
| I.H.S Health, LLC Coordinator of this site? Confirm its status | Kissimmee | United States | Unknown status |
| Caprock Gastro Research Coordinator of this site? Confirm its status | Lubbock | United States | Unknown status |
| Tandem Clinical Research Coordinator of this site? Confirm its status | Marrero | United States | Unknown status |
| Gastroenterology of Southern Indiana Coordinator of this site? Confirm its status | New Albany | United States | Unknown status |
| Hoag Memorial Hospital Coordinator of this site? Confirm its status | Newport Beach | United States | Unknown status |
| New York Gastroenterology Associates Coordinator of this site? Confirm its status | New York | United States | Unknown status |
| DiGiovanna Institute for Medical Education & Research Coordinator of this site? Confirm its status | North Massapequa | United States | Unknown status |
| Care Access Research, Ogden Coordinator of this site? Confirm its status | Ogden | United States | Unknown status |
| Digestive Disease Specialists, Inc Coordinator of this site? Confirm its status | Oklahoma City | United States | Unknown status |
| Endoscopic Research, Inc Coordinator of this site? Confirm its status | Orlando | United States | Unknown status |
| Mayo Clinic - Rochester Coordinator of this site? Confirm its status | Rochester | United States | Unknown status |
| Southern Star Research Institute, LLC Coordinator of this site? Confirm its status | San Antonio | United States | Unknown status |
| Medical Associates Research Group, Inc. Coordinator of this site? Confirm its status | San Diego | United States | Unknown status |
| Washington Gastroenterology, PLLC 1 Coordinator of this site? Confirm its status | Tacoma | United States | Unknown status |
| GCP Clinical Research Coordinator of this site? Confirm its status | Tampa | United States | Unknown status |
| Cotton O'Neil Digestive Health Center Coordinator of this site? Confirm its status | Topeka | United States | Unknown status |
| Tyler Research Institute, LLC Coordinator of this site? Confirm its status | Tyler | United States | Unknown status |
| Northshore Gastroenterology Research, LLC Coordinator of this site? Confirm its status | Westlake | United States | Unknown status |
| Gazi University Medical Faculty Coordinator of this site? Confirm its status | Ankara | Turkey (Türkiye) | Unknown status |
| Uludag Universitesi Tıp Fakultesi Hastanesi Coordinator of this site? Confirm its status | Bursa | Turkey (Türkiye) | Unknown status |
| Ege Universitesi Tip Fakultesi Coordinator of this site? Confirm its status | Izmir | Turkey (Türkiye) | Unknown status |
| Mersin University Medical Faculty Coordinator of this site? Confirm its status | Mersin | Turkey (Türkiye) | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.