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NCT06049017CompletedPhase 2

A Study of JNJ-77242113 in Participants With Moderately to Severely Active Ulcerative Colitis

A Phase 2b Multicenter, Randomized, Placebo- Controlled, Dose-Ranging Study to Evaluate the Efficacy and Safety of JNJ-77242113 for the Treatment of Moderately to Severely Active Ulcerative Colitis

Source: ClinicalTrials.gov · Last updated 13 Apr 2026

Brief summary (registry, in English)

The purpose of this study is to evaluate the safety and effectiveness of JNJ-77242113 compared with placebo in participants with moderately to severely active ulcerative colitis.

Status (registry)
Completed
Phase (registry)
Phase 2
Study type
Interventional
Enrollment
252 (actual)
First submitted
15 Sept 2023
Start date
9 Oct 2023
Primary completion date
26 Sept 2024
Lead sponsor
Janssen Research & Development, LLC
NCT number
NCT06049017
EU CT number
2023-504673-20-00

What you commit to

  • Study type: Interventional · Phase 2
  • Participants enrolled: 252
  • From 9 Oct 2023 to the primary completion date, 26 Sept 2024
  • 178 sites in 21 countries
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Prior treatment

  • Participants with current or prior diagnosis of fulminant colitis and/or toxic megacolon

Other illness

  • Presence or history of fistula
  • History of extensive colonic resection (example, \<30 cm of colon remaining)
  • Diagnosis of indeterminate colitis, microscopic colitis, ischemic colitis, Crohn's colitis or clinical findings suggestive of Crohn's disease

Other

  • UC limited to rectum only or to less than (\<) 15 centimeters (cm) of colon
  • Presence of a stoma

Who the study is looking for

  • Signed informed consent form 18 years of age or older
  • Documented diagnosis of ulcerative colitis (UC) of at least 12 weeks prior to screening
  • Moderately to severely active UC as per the modified Mayo score
  • Demonstrated inadequate response to or intolerance of conventional therapy and/or advanced therapy as defined in the protocol

Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (178)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
CIPREC
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Buenos AiresArgentinaUnknown status
Gedyt - Consultorios Gastroenterologia
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Buenos AiresArgentinaUnknown status
Cer Instituto Medico
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Buenos AiresArgentinaUnknown status
Hospital Provincial del Centenario
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RosarioArgentinaUnknown status
Sanatorio 9 de Julio
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San Miguel de TucumánArgentinaUnknown status
Sunshine Coast University Hospital
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BirtinyaAustraliaUnknown status
Blacktown Hospital
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BlacktownAustraliaUnknown status
Concord Repatriation General Hospital
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ConcordAustraliaUnknown status
Wollongong Private Hospital
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WollongongAustraliaUnknown status
CHU Saint-Pierre
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BrusselsBelgiumCompleted
Universitair Ziekenhuis Gent
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GentBelgiumCompleted
AZ Sint-Lucas & Volkskliniek
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GentBelgiumCompleted
UZ Leuven
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LeuvenBelgiumCompleted
CHU de Liège
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LiègeBelgiumCompleted
Vitaz
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Sint-NiklaasBelgiumCompleted
Unesp - Faculdade de Medicina Da Universidade Estadual Paulista - Campus Botucatu
Coordinator of this site? Confirm its status
BotucatuBrazilUnknown status
L2IP - Instituto de Pesquisas Clínicas
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BrasíliaBrazilUnknown status
CDC - Centro Digestivo de Curitiba
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CuritibaBrazilUnknown status
Hospital de Clinicas de Porto Alegre - Hospital de Clinicas
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Porto AlegreBrazilUnknown status
Pesquisare Saude
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Santo AndréBrazilUnknown status
BR Trials - Ensaios Clínicos e Consultoria Ltda.
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São PauloBrazilUnknown status
Instituto D'or de Pesquisa e Ensino
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São PauloBrazilUnknown status
Integral Pesquisa e Ensino
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VotuporangaBrazilUnknown status
Barrie GI Associates
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BarrieCanadaUnknown status
Gastroenterology and Internal Medicine Research Institute (GIRI)
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EdmontonCanadaUnknown status
London Health Sciences Centre
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LondonCanadaUnknown status
Centre Hospitalier de l'Université de Montréal
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MontrealCanadaUnknown status
ABP Research Services Corp.
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OakvilleCanadaUnknown status
The Second Xiangya Hospital of Central South University
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ChangshaChinaUnknown status
Chongqing General Hospital
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ChongqingChinaUnknown status
The Sixth Affiliated Hospital, Sun Yat-sen University
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GuangzhouChinaUnknown status
The First Affiliated Hospital, Sun Yat-sen University
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GuangzhouChinaUnknown status
Sir Run Run Shaw Hospital Zhejiang University School of Medicine
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HangzhouChinaUnknown status
Qilu Hospital of Shandong University
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JinanChinaUnknown status
Lanzhou University Second Hospital
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LanzhouChinaUnknown status
Nanjing Drum Tower hospital
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NanjingChinaUnknown status
Shengjing Hospital Of China Medical University
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ShenyangChinaUnknown status
Union Hospital Tongji Medical College of Huazhong University of Science and Technology
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WuhanChinaUnknown status
Wuxi People's Hospital
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WuxiChinaUnknown status
The Second Affiliated Hospital of Air Force Medical University - Tangdu Hospital
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Xi'anChinaUnknown status
Nemocnice České Budějovice, a.s.
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České BudějoviceCzechiaCompleted
Hepato-Gastroenterologie HK, s.r.o.
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Hradec KrálovéCzechiaCompleted
Gastroenterologie s.r.o.
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Hradec KrálovéCzechiaCompleted
ISCARE a.s.
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PragueCzechiaCompleted
Nemocnice Slany
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SlanýCzechiaCompleted
Universitaetsklinikum Augsburg
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AugsburgGermanyCompleted
Krankenhaus Waldfriede e.V.
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BerlinGermanyCompleted
Technische Universität Dresden
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DresdenGermanyCompleted
Medizinische Hochschule Hannover
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HanoverGermanyCompleted
Universitaetsklinikum Schleswig-Holstein
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KielGermanyCompleted
Eugastro GmbH
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LeipzigGermanyCompleted
Staedtisches Klinikum Lueneburg gGmbH
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LueneburgGermanyCompleted
Gastroenterologische Gemeinschaftspraxis Minden
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MindenGermanyCompleted
Area Sanitaria De Ferrol
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FerrolSpainCompleted
Hospital Universitario de Cabueñes
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GijónSpainCompleted
Hospital Universitario La Paz
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MadridSpainCompleted
Hospital Universitario Fundacion Alcorcon
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MadridSpainCompleted
Hospital Universitario Puerta de Hierro de Majadahonda
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MajadahondaSpainCompleted
Complexo Hospitalario Universitario De Santiago
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Santiago de CompostelaSpainCompleted
Hospital Universitario Virgen De La Macarena
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SevillaSpainCompleted
Hospital Universitario Virgen De Valme
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SevillaSpainCompleted
Hospital Clinico Universitario de Valencia
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ValenciaSpainCompleted
Hospital Universitario Y Politecnico La Fe
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ValenciaSpainCompleted
Complexo Hospitalario Universitario De Vigo
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VigoSpainCompleted
Besancon University Hospital Center
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Besancon CedexFranceCompleted
Assistance Publique Hopitaux De Paris
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CreteilFranceCompleted
Centre Hospitalier Universitaire De Lille
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Lille CedexFranceCompleted
Centre Medico Chirurgical Ambroise Pare Hartmann
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Neuilly-Sur-SeineFranceCompleted
Centre Hospitalier Universitaire de Nice
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NiceFranceCompleted
Centre Hospitalier Universitaire De Nimes
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Nimes Cedex 9FranceCompleted
Assistance Publique Hopitaux De Paris
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Paris Cedex 18FranceCompleted
Hospices Civils de Lyon
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Pierre-BéniteFranceCompleted
Centre Hospitalier Universitaire de Saint Etienne
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Saint-EtienneFranceCompleted
Centre Hospitalier Universitaire De Toulouse
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Toulouse Cedex 9FranceCompleted
CHRU De Nancy
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Vandoeuvre Les NancyFranceCompleted
Fairfield General Hospital
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BuryUnited KingdomUnknown status
Addenbrookes Hospital
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CambridgeUnited KingdomUnknown status
Barts Health NHS Trust
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LondonUnited KingdomUnknown status
St Georges University Hospital NHS Foundation Trust
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LondonUnited KingdomUnknown status
Guys & St Thomas Hospital
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LondonUnited KingdomUnknown status
Kings College Hospital
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LondonUnited KingdomUnknown status
Oxford University Hospitals NHS Foundation Trust
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OxfordUnited KingdomUnknown status
Whiston Hospital
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PrescotUnited KingdomUnknown status
Southampton University Hospital
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SouthamptonUnited KingdomUnknown status
Semmelweis University
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Budapest VIIIHungaryCompleted
Pannonia Maganorvosi Centrum Kft.
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Budapest XIIIHungaryCompleted
University of Debrecen
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DebrecenHungaryCompleted
Vasutegeszseguegyi Nonprofit Koezhasznu Kft.
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DebrecenHungaryCompleted
Bugat Pal Korhaz Kht.
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GyongyosHungaryCompleted
S. R. Kalla Memorial General Hospital
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JaipurIndiaUnknown status
Midas Hospital
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NagpurIndiaUnknown status
Govind Ballabh Pant Hospital
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New DelhiIndiaUnknown status
SIDS Hospital & Research Centre
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SuratIndiaUnknown status
ARNAS G. Brotzu
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CagliariItalyCompleted
Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico
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MilanItalyCompleted
Ospedale San Raffaele S.r.l.
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MilanItalyCompleted
IRCCS Ospedale Sacro Cuore Don Calabria
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NegrarItalyCompleted
Azienda Ospedale Universita Padova
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PadovaItalyCompleted
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
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RomeItalyCompleted
San Camillo Forlanini Hospital
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RomeItalyCompleted
Humanitas Research Hospital
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RozzanoItalyCompleted
Casa Sollievo della Sofferenza
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San Giovanni RotondoItalyCompleted
Sai Gastroenterology Proctology
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Fujiidera-shiJapanUnknown status
Hamamatsu University Hospital
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HamamatsuJapanUnknown status
Kagoshima IBD Gastroenterology Clinic
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KagoshimaJapanUnknown status
Tsujinaka Hospital Kashiwanoha
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KashiwaJapanUnknown status
Aoyama Naika Clinic
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KobeJapanUnknown status
Kinshukai Infusion Clinic
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OsakaJapanUnknown status
Japanese Red Cross Osaka Hospital
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OsakaJapanUnknown status
Toho University Sakura Medical Center
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SakuraJapanUnknown status
Sapporo Higashi Tokushukai Hospital
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SapporoJapanUnknown status
Sapporo Tokushukai Hospital
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SapporoJapanUnknown status
National Hospital Organization Shizuoka Medical Center
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ShimizuJapanUnknown status
Tokyo Metropolitan Bokutoh Hospital
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Sumida-kuJapanUnknown status
Mie University Hospital
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TsuJapanUnknown status
Yokohama City University Medical Center
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YokohamaJapanUnknown status
Inje University Haeundae Paik Hospital
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BusanSouth KoreaUnknown status
Yeungnam University Hospital
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DaeguSouth KoreaUnknown status
Asan Medical Center
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SeoulSouth KoreaUnknown status
Kangbuk Samsung Hospital
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SeoulSouth KoreaUnknown status
Samsung Medical Center
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SeoulSouth KoreaUnknown status
Seoul National University Hospital
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SeoulSouth KoreaUnknown status
The Catholic University of Korea St. Vincent's Hospital
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SuwonSouth KoreaUnknown status
Hospital Sultanah Aminah
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Johor BahruMalaysiaUnknown status
Sultan Idris Shah Hospital
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KajangMalaysiaUnknown status
University Malaya Medical Centre
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Kuala LumpurMalaysiaUnknown status
Manermed Sp. z o.o.
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BydgoszczPolandCompleted
Centrum Medyczne Lukamed Joanna Luka
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ChojnicePolandCompleted
Centrum Medyczne Plejady Sp. z o.o. S.K.
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CracowPolandCompleted
Centrum Medyczne Medyk Sp. z o.o.
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RzeszowPolandCompleted
Sonomed Sp. z o.o.
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SzczecinPolandCompleted
GASTROMED Sp. z o.o.
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TorunPolandCompleted
Bodyclinic sp. z o.o. sp.k.
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WarsawPolandCompleted
Panstwowy Instytut Medyczny Ministerstwa Spraw Wewnetrznych i Administracji
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WarsawPolandCompleted
Medical Network Sp z o o
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WarsawPolandCompleted
Centrum Medyczne Oporow
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WroclawPolandCompleted
Melita Medical Sp. z o.o.
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WroclawPolandCompleted
EMC Instytut Medyczny S.A.
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WroclawPolandCompleted
Delta Health Care S.R.L
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BucharestRomaniaCompleted
Spitalul De Oncologie Monza S.R.L.
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BucharestRomaniaCompleted
Tvm Med Serv S.R.L.
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Cluj-NapocaRomaniaCompleted
Valahia Medical S.R.L.
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PloiestiRomaniaCompleted
Clinnova Research
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AnaheimUnited StatesUnknown status
Atlanta Gastroenterology Associates
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AtlantaUnited StatesUnknown status
Mercy Medical Center
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BaltimoreUnited StatesUnknown status
Washington Gastroenterology, PLLC
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BellevueUnited StatesUnknown status
UNC Hospitals
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Chapel HillUnited StatesUnknown status
Atrium Health
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CharlotteUnited StatesUnknown status
Charlotte Gastroenterology and Hepatology, PLLC
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CharlotteUnited StatesUnknown status
Gastroenterology Associates of Tidewater
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ChesapeakeUnited StatesUnknown status
Peak Gastroenterology Associates
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Colorado SpringsUnited StatesUnknown status
DHAT Research Institute
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GarlandUnited StatesUnknown status
Amel Med LLC Research
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GeorgetownUnited StatesUnknown status
Gastroenterology Associates P.A.
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GreenvilleUnited StatesUnknown status
Accurate Clinical Research, Inc
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HumbleUnited StatesUnknown status
Ochsner Medical Center
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JeffersonUnited StatesUnknown status
I.H.S Health, LLC
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KissimmeeUnited StatesUnknown status
Caprock Gastro Research
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LubbockUnited StatesUnknown status
Tandem Clinical Research
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MarreroUnited StatesUnknown status
Gastroenterology of Southern Indiana
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New AlbanyUnited StatesUnknown status
Hoag Memorial Hospital
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Newport BeachUnited StatesUnknown status
New York Gastroenterology Associates
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New YorkUnited StatesUnknown status
DiGiovanna Institute for Medical Education & Research
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North MassapequaUnited StatesUnknown status
Care Access Research, Ogden
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OgdenUnited StatesUnknown status
Digestive Disease Specialists, Inc
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Oklahoma CityUnited StatesUnknown status
Endoscopic Research, Inc
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OrlandoUnited StatesUnknown status
Mayo Clinic - Rochester
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RochesterUnited StatesUnknown status
Southern Star Research Institute, LLC
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San AntonioUnited StatesUnknown status
Medical Associates Research Group, Inc.
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San DiegoUnited StatesUnknown status
Washington Gastroenterology, PLLC 1
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TacomaUnited StatesUnknown status
GCP Clinical Research
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TampaUnited StatesUnknown status
Cotton O'Neil Digestive Health Center
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TopekaUnited StatesUnknown status
Tyler Research Institute, LLC
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TylerUnited StatesUnknown status
Northshore Gastroenterology Research, LLC
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WestlakeUnited StatesUnknown status
Gazi University Medical Faculty
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AnkaraTurkey (Türkiye)Unknown status
Uludag Universitesi Tıp Fakultesi Hastanesi
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BursaTurkey (Türkiye)Unknown status
Ege Universitesi Tip Fakultesi
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IzmirTurkey (Türkiye)Unknown status
Mersin University Medical Faculty
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MersinTurkey (Türkiye)Unknown status

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