NCT06051110Completed
Individual Patient Data Meta-analysis on Prehospital Risk Assessment in Patients Suspected of Non-ST-segment Elevation Acute Coronary Syndrome
Source: ClinicalTrials.gov · Last updated 18 Mar 2026
Brief summary (registry, in English)
Patients with a non-ST-segment elevation acute coronary syndrome (NSTE-ACS) are currently transported and admitted to the nearest emergency department (ED) for risk stratification, diagnostic workup, and treatment. Recently, several prospective studies have been performed on the diagnostic performance of point-of-care (POC)-troponin and combined risk scores (CRS) for pre-hospital risk assessment and triage of NSTE-ACS patients. Also the first intervention trials on triage decisions based on POC troponin and CRS have been performed. Initial results are indicating that prehospital triage based on these diagnostic tools is feasible and safe, although sample sizes were relatively small and underpowered to detect differences in major adverse cardiac events (MACE). The objective of this individual patient data meta-analysis is to determine the diagnostic performance of POC troponin and combined risk scores for prehospital risk assessment and triage in suspected NSTE-ACS patients.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 5239 (actual)
- First submitted
- 4 Sept 2023
- Start date
- 1 Oct 2023
- Primary completion date
- 1 Dec 2024
- Lead sponsor
- Catharina Ziekenhuis Eindhoven
- Diseases
- Coronary artery disease
- NCT number
- NCT06051110
What you commit to
- Study type: Interventional
- Participants enrolled: 5239
- From 1 Oct 2023 to the primary completion date, 1 Dec 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other
- Enrolling only a specific subpopulation from the general ACS population
- Studies with less than 100 patients
- Studies enrolling only patients with STEMI.
- Studies published before 1995 / the pre-troponin era
- Studies performed by general practitioners.
Who the study is looking for
- Patients suspected for NSTE-ACS;
- Prospective study
- Original data
- Presenting prehospital (EMS)
- Prehospital risk assessment using at least POC-troponin, performed and analyzed by EMS.
- Outcome data available on in-hospital ACS or MACE within 30 days.
Age in the registry: 18 years to - · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Catharina Hospital Eindhoven Coordinator of this site? Confirm its status | Eindhoven | Netherlands | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.