NCT06053216Completed
Indirect Calorimetry Guided Energy Provision in Critically Ill Patients With Obesity
GuiDIng Energy Provision Using indiREct CalorimeTry: a Pilot Feasibility Randomised Controlled Trial in Critically Ill Adults With Obesity
Source: ClinicalTrials.gov · Last updated 22 May 2026
Brief summary (registry, in English)
The DIRECT trial is a prospective, multi-centre, two arm parallel feasibility pilot randomised controlled trial. The primary aim is to determine the feasibility of using repeat indirect calorimetry measurements to direct energy delivery in critically ill patients with obesity. The trial will recruit 60 mechanically ventilated patients from 4-6 ICUs in Australia and New Zealand.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 60 (actual)
- First submitted
- 21 Aug 2023
- Start date
- 16 Oct 2023
- Primary completion date
- 3 Nov 2025
- Lead sponsor
- Australian and New Zealand Intensive Care Research Centre
- Diseases
- Obesity
- NCT number
- NCT06053216
What you commit to
- Study type: Interventional
- Participants enrolled: 60
- From 16 Oct 2023 to the primary completion date, 3 Nov 2025
- 5 sites in 2 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Receiving extracorporeal membrane oxygenation support
Other
- Major burns (≥20% total body surface area)
- Unable to perform indirect calorimetry within 24 hours of randomisation
- Known pregnancy
- Death is imminent
- Treating clinician believes the study is not in the best interest of the patient
Who the study is looking for
- Adult (≥ 18 years) patients
- Body mass index ≥30 kg/m2
- Between day 3 and 6 of index ICU admission
- Receiving invasive mechanical ventilation
- Receiving enteral or parenteral nutrition
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (5)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Ballarat Base Hospital, Grampians Health Coordinator of this site? Confirm its status | Ballarat Central | Australia | Unknown status |
| Blacktown Hospital Coordinator of this site? Confirm its status | Blacktown | Australia | Unknown status |
| Royal Prince Alfred Hospital Coordinator of this site? Confirm its status | Camperdown | Australia | Unknown status |
| The Alfred Hospital Coordinator of this site? Confirm its status | Melbourne | Australia | Unknown status |
| Department of Critical Care Medicine, Auckland City Hospital Coordinator of this site? Confirm its status | Auckland | New Zealand | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.