NCT06057207Completed
Perioperative Blood Adiponectin Dynamics and Systemic Infflamatory Response After Major Colorectal Surgery
Effects of Perioperative Circulating Adiponectin Levels on Postoperative Systemic Inflammatory Response in Patients Undergoing Major Colorectal Surgery
Source: ClinicalTrials.gov · Last updated 29 Aug 2025
Brief summary (registry, in English)
Surgical stress after major abdominal surgery in perioperative period causes neuroendocrine, metabolic and imunologic changes in organism with production of proinfflamatory citokines and results with appearance of systemic infflammmatory response syndrome (SIRS). Dysregulated and overrated SIRS in early postoperative period can lead to complications with additional comorbidities, longer hospital stay and poorer outcome. A low grade chronic infflammatory state in obesity and hypoadiponectinemia can enable the cytokine storm and exaggerated /dysregulated SIRS in obese patients after surgery. Obesity according to this knowledge presents independent risk factor for developing more severe systemic infflamatory response syndrome in early postoperative period after major abdominal surgery. Also, chronic intestinal and gut infflamation is leading theory in oncogenesis of colorectal carcinoma according to recent findings. Many studies find low adiponectin levels in patients with colorectal carcinoma compared to healthy population. Obesity and colorectal cancer have infflamation and low adiponectin level as mutual factor which can be the important key in pathophysiology process of colorectal oncogenesis which are extremly complicated , multifactorial and intertwining. Hypothesis: Lower blood adiponectin levels are associated with higher systemic infflamatory response in patients after major abdominal surgery. Major aim of this study is to investigate correlation between perioperative blood levels of adiponectin and clinical signs of systemic infflamation and blood markers of systemic infflamation in patients after major colorectal surgery.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 58 (actual)
- First submitted
- 19 Sept 2023
- Start date
- 27 Jul 2023
- Primary completion date
- 1 May 2025
- Lead sponsor
- Osijek University Hospital
- Diseases
- Obesity, Colorectal cancer
- NCT number
- NCT06057207
What you commit to
- Study type: Observational
- Participants enrolled: 58
- From 27 Jul 2023 to the primary completion date, 1 May 2025
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Age\<18 years BMI\<18.5kg/m2 Acute surgical conditions Established acute systemic/local infection Chronic/actual corticosteroid therapy Active immunomodulation therapy Allergie to used anestehetics/analgetics in study. Patient refusal Laparoscopic surgery Massive intraoperative surgical bleeding Preexisting concomitant second carcinoma other than colorectal origin Patients which does not fulfill inclusion criteria
Who the study is looking for
- Diagnose of colorectal cancer Age \>18 years Patient presenting for major (open) elective colorectal surgery according to carcinoma.
- Written informed consent.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Sonja Škiljić Coordinator of this site? Confirm its status | Osijek | Croatia | Unknown status |
| Osijek University Hospital Coordinator of this site? Confirm its status | Osijek | Croatia | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.