A Study to Evaluate the Relative Bioavailability of Subcutaneous Bepirovirsen When Delivered From a Vial or Prefilled Syringe Fitted With a Safety Syringe Device in Healthy Adult Participants

Prior treatment

• Past, current or intended use of over the counter or prescription medication \[including herbal medications\]
• Current or prior use of creatine-containing supplements and intended use up to 50 days post-dosing.
  • Prior use of immunosuppressive drugs within 3 months before dosing or interferon within 12 months before dosing.
• Prior treatment with any oligonucleotide or small interfering ribonucleoside (RNA) siRNA within 12 months before dosing.
• Exposure to more than 4 new chemical entities within 12 months prior to the first dosing day.
• Current enrolment or past participation in another investigational study in which an investigational intervention (e.g., drug, vaccine, invasive device) was administered within 5-half-lives (if known) or twice the duration of biological effect (if known), whichever is longer, or within the last 90 days (if half-life and duration of biological effect are unknown), before the first dosing day in the current study.
• Cotinine levels indicative of smoking or history or regular use of tobacco- or nicotine-containing products within 6 months prior to screening.
• Regular alcohol consumption of alcohol within 6 months prior to the study.
• Regular use of known drugs of abuse, including Tetrahydrocannabinol (THC).

Other illness

• Past or current medical conditions which, in the judgement of the investigator and Medical Monitor, could jeopardize the integrity of the data derived from that participant or the safety of the participant.
• Positive Hepatitis B virus (HBV), Hepatitis C virus (HCV) or human immunodeficiency virus (HIV) test results.
• Participants with signs or symptoms suggestive of Coronavirus disease 2019 (COVID-19) within 14 days of inpatient admission, or with a positive test for active COVID-19 infection before study start.
• History of sensitivity to bepirovirsen or components thereof or a history of drug or other allergy that, in the opinion of the investigator or Medical Monitor contraindicates their participation.

Other

• Abnormal blood pressure as determined by the investigator.
• Loss of blood or blood products in excess of 500 millilitre (mL) within any 3-month period during the study.
• Current enrolment or past participation in this clinical study.

• Healthy participants as determined by medical evaluation including medical history, physical examination, laboratory tests, electrocardiogram (ECGs) and vital signs.
• Capable of giving signed informed consent which includes compliance with the requirements and restrictions listed in the ICF and protocol.