NCT06058702RecruitingPhase 1
Genetic Basis of the Risk and Consequences of Cannabis Exposure in Humans
Source: ClinicalTrials.gov · Last updated 2 Sept 2026
Brief summary (registry, in English)
Cannabis is widely used worldwide and is associated with negative outcomes including cannabis use disorder (CanUD), psychosis, and cognitive impairment amongst others. Given the legalization of "recreational" and "medical" cannabis globally, the increasing availability of cannabis, the higher potency of cannabis, the availability of highly potent cannabinoid products, the commercialization of cannabis, and the rising rates of cannabis use, it is critical to understand how genetic factors influence 1) an individual's vulnerability for addiction and psychosis, 2) the response to cannabinoids, 3) the response to novel treatments for CanUD. CanUD is strongly genetically influenced; the investigators published the first CanUD genomewide association study (GWAS) with genomewide-significant results; however, the precise nature of the contribution of genetic factors in the development of CanUD is still not clear. Cannabis exposure has also been linked to a number of psychosis outcomes including schizophrenia (SCZ). SCZ is highly heritable and population-based and genetics studies both support a bidirectional genetic relationship between SCZ and CanUD. However, the precise contribution of genetic factors in the development of psychosis outcomes related to cannabis are not clear.
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 1
- Study type
- Interventional
- Enrollment
- 215 (estimated)
- First submitted
- 15 Sept 2023
- Start date
- 16 Sept 2024
- Primary completion date
- 31 Dec 2028
- Lead sponsor
- Yale University
- Diseases
- Schizophrenia
- NCT number
- NCT06058702
What you commit to
- Study type: Interventional · Phase 1
- Planned participants: 215
- From 16 Sept 2024 to the primary completion date, 31 Dec 2028
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Lab values
- Major or unstable medical conditions based on history, the Structured Clinical Interview for DSM-5, collateral information, physical and laboratory examinations, ECG, and vital signs.
Other
- Cannabis naïve individuals
- Positive pregnancy test
Who the study is looking for
- -Ages 21-60 years old
Age in the registry: 21 years to 60 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| West Haven Veterans Affairs Medical Center Coordinator of this site? Confirm its status | West Haven | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.