NCT06059872Recruiting
Biomarkers of Reaction To HIIT Exercise
What Makes a Responder, a Responder? Biomarkers to Help Identify Responders and Resistors to High-intensity Interval Training for Lower Extremity Chronic Stroke
Source: ClinicalTrials.gov · Last updated 27 Mar 2026
Brief summary (registry, in English)
Stroke survivors with lower limb disability can improve their walking speed with high-intensity interval training (HIIT) rehabilitation therapy. However, some individuals may not respond to HIIT even when fully adherent to the program. To address this, the investigators propose to build a predictive model that identifies if a Veteran with chronic subcortical stroke will improve their walking speed with HIIT by incorporating blood lactate as an early predictor of exercise response, and inhibitory neurotransmitter gamma-aminobutyric acid (GABA) and regional cerebral blood flow (CBF) as predictors of the brain's potential to respond, while also taking into consideration other factors such as comorbidities, demographics, and fitness levels.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 55 (estimated)
- First submitted
- 18 Sept 2023
- Start date
- 1 Jan 2024
- Primary completion date
- 1 Jun 2027
- Lead sponsor
- VA Office of Research and Development
- Diseases
- Stroke
- NCT number
- NCT06059872
What you commit to
- Study type: Interventional
- Planned participants: 55
- From 1 Jan 2024 to the primary completion date, 1 Jun 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- MRI contraindications, including implanted cardiac pacemakers and severe claustrophobia
- any neurodegenerative condition other than stroke that may lead to lower extremity impairment
- a visual or auditory impairment that may hinder study procedures
- any medical condition that would preclude participation in a physical exercise intervention program
Who the study is looking for
- chronic left or right subcortical stroke as defined by 6 months or more after a cardiovascular accident
- lower extremity motor impairment due to stroke that causes a walking speed of less than 0.6 m/s during a 10m walk
- Veteran status
Age in the registry: 18 years to 89 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Atlanta VA Medical and Rehab Center, Decatur, GA Coordinator of this site? Confirm its status | Decatur | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.