Low-Frequency REpetitive TRanscranial Magnetic Stimulation in ACute Ischemic StrokE Within 48 Hours

Prior treatment

• TMS contraindications include metallic foreign bodies in the head, pacemaker, implantable drug pumps, cochlear implants, etc.
• Participants in other clinical intervention studies within 30 days before randomization or who were participating in other clinical intervention studies.

Other illness

• Epilepsy or history of epilepsy, intracranial hypertension, tumor and other serious neurological disorders;
• Evidence of acute intracranial hemorrhage;
• A history of congenital or acquired hemorrhagic disease, coagulation factor deficiency, or thrombocytopenia disease;
• Patients with severe mental disorders or dementia who can not cooperate with informed consent and follow-up;
• Patients with malignancy or severe systemic disease and expected survival of less than 90 days;

Lab values

• Known recent or current serum creatinine exceeding 1.5 times the upper limit of normal or estimated glomerular filtration rate (EGFR) \< 60 mL/min;

Other

• Midline displacement and brain parenchymal mass effect seen in head CT and other images;
• Head CT or MRI showed bilateral acute cerebral infarction, brainstem infarction, or insular infarction;
• After blood pressure control, the systolic blood pressure was still ≥180 mmHg or the diastolic blood pressure was ≥110 mmHg;
• Patients during pregnancy or lactation and within 90 days of planned pregnancy;

• Age 18-80 years, gender is not limited;
• Acute ischemic stroke of anterior circulation was diagnosed clinically
• mRS 0-1 score before onset;
• 6 ≤ NIHSS ≤25 at randomization;
• Within 48 hours of stroke onset;
• No thrombolysis therapy or thrombectomy is planned;
• Obtain informed consent signed by the patient himself or by his legal authorized representative.