NCT06070428Recruiting
Project 4: ACHIEVE PATHFINDER
ACHIEVE GREATER: Addressing Cardiometabolic Health In Populations Through Early Prevention in the GREAT LakEs Region Project 4: Portable Air Cleaners to Treat Heart Failure and Negate Disparities of Environment and Race (PATHFINDER)
Source: ClinicalTrials.gov · Last updated 7 Jul 2026
Brief summary (registry, in English)
ACHIEVE-P4: PATHFINDER is a randomized, blinded clinical trial of portable air cleaners (PAC) provided at the time of hospital discharge to Heart Failure (HF) patients. It will be carried out at Henry Ford Hospitals. This project is part of the ACHIEVE GREATER (Addressing Cardiometabolic Health In Populations Through Early PreVEntion in the GREAT LakEs Region) Center (IRB 100221MP2A). The ACHIEVE GREATER Center involves several separate but related projects that aim to prolong lifespan among Detroit, MI and Cleveland, OH, for three chronic conditions, hypertension (HTN, Project 1), heart failure (HF, Projects 2 \& 4) and coronary heart disease (CHD, Project 3). The present study is Project 4 (Aim 1) a randomized clinical trial titled: Portable Air cleaners to Treat Heart Failure and Negate Disparities of Environment and Race (PATHFINDER), of the ACHIEVE GREATER Center. Project 4 is a randomized, double-blind, parallel limb trial of 400 patients with hospitalized HF who will be provided active PAC vs sham at discharge from HFH. Participants will receive two PACs at discharge and an indoor PM2.5 sensor. PACs will be randomized to either active PAC with HEPA filters or sham PAC without HEPA filters. Researchers will compare the following outcomes of the two groups (more outcomes below in Outcome Measures section): 1. Change in NTproBNP from baseline to 90 days 2. Home PM2.5 levels from baseline to 90 days 3. Clinical events such as death and hospitalization will be monitored
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 400 (estimated)
- First submitted
- 26 Sept 2023
- Start date
- 18 Dec 2023
- Primary completion date
- Jun 2027
- Lead sponsor
- Henry Ford Health System
- Diseases
- Heart failure
- NCT number
- NCT06070428
What you commit to
- Study type: Interventional
- Planned participants: 400
- From 18 Dec 2023 to the primary completion date, Jun 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Has a scheduled, non-diagnostic cardiac procedure within 30 days prior, or in the next 90 days from screening (e.g. PCI, resynchronization, any cardiac surgery)
Other illness
- Heart transplant recipients
- Severe aortic or mitral valve disease
Lab values
- If dialysis is being considered by participant's care team and their eGFR value is \<30 mL/min/1.73 sq m
Age
- Age less than 18 years old
Other
- Hemodialysis dependent
- Life expectancy of less than one year
- Inability to provide written informed consent
- Patients with a left ventricular assist device (LVAD)
- Individuals who regularly use a HEPA air cleaner in their home at screening
- Current smokers of nicotine or marijuana
- If the PI decides for any reason that participation in the trial is not in the best interest of the patient
Who the study is looking for
- Currently in the emergency room or hospitalized with plan to be discharged to home, or
- Diagnosis of heart failure
- BNP\>200 ng/L or NTproBNP\>1000 ng/L during hospitalization or within 1 month prior to screening
- Expected ability to fully participate in study (can tolerate study processes, no long travel)
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Henry Ford Health Coordinator of this site? Confirm its status | Detroit | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.