NCT06073587Completed
The CARDIO-TTRansform Scintigraphy Sub-study
CARDIO-TTRansform ION-682884-CS2-Scintigraphy Sub-study
Source: ClinicalTrials.gov · Last updated 11 Sept 2026
Brief summary (registry, in English)
The purpose of this study is to examine the changes in amyloid myocardial burden in a subset of the population participating in the ION682884-CS2 (NCT04136171) study, up to 150 participants, after treatment with eplontersen or placebo based on scintigraphy scans performed at Week 140 using the Perugini grade score method.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 163 (actual)
- First submitted
- 4 Oct 2023
- Start date
- 4 Apr 2023
- Primary completion date
- 25 Mar 2026
- Lead sponsor
- Ionis Pharmaceuticals, Inc.
- Diseases
- Amyloidosis
- NCT number
- NCT06073587
What you commit to
- Study type: Observational
- Participants enrolled: 163
- From 4 Apr 2023 to the primary completion date, 25 Mar 2026
- 5 sites in 2 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Should not have any previously reported hypersensitivity reaction to Technetium-99m.
Other
- Must not meet any of the exclusion criteria of the study protocol ION-682884-CS2 (NCT04136171).
- Must not have weight or body girth that exceeds the limits of the equipment specifications.
Who the study is looking for
- Participants must have been properly randomized into the ION-682884-CS2 study (NCT04136171) and should have had a baseline scintigraphy scan (99mTc-DPD, 99mTc- PYP, and 99mTc-HMDP) within 12 months prior to screening for ION-682884-CS2 with planar and SPECT or SPECT/CT images that can be read by the central reader.
Age in the registry: 18 years to 90 years · Sex: All · Does not accept healthy volunteers
Sites (5)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Hospital Universitario Puerta de Hierro Coordinator of this site? Confirm its status | Majadahonda | Spain | Unknown status |
| Cleveland Clinic - Main Campus Coordinator of this site? Confirm its status | Cleveland | United States | Unknown status |
| Duke University Medical Center Coordinator of this site? Confirm its status | Durham | United States | Unknown status |
| Columbia University Irving Medical Center Coordinator of this site? Confirm its status | New York | United States | Unknown status |
| Oregon Health and Science University Coordinator of this site? Confirm its status | Portland | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.