NCT06079294Recruiting
Impact of Confirmed Autoimmune Encephalitis on Brain Glucose Metabolism
Impact of Confirmed Autoimmune Encephalitis on Brain Glucose Metabolism : a Prospective FDG PET Study
Source: ClinicalTrials.gov · Last updated 22 Aug 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
Prospective cohort study evaluating FDG PET in 56 patients with confirmed autoimmune encephalitis - based on 2016 Graus criteria, and 2021 paraneoplastic neurological syndromes criteria - at the acute phase, before immunomodulating treatment, or within 10 days of treatment initiation.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 56 (estimated)
- First submitted
- 6 Oct 2023
- Start date
- 31 May 2024
- Primary completion date
- 30 Apr 2026
- Lead sponsor
- Assistance Publique - Hôpitaux de Paris
- NCT number
- NCT06079294
What you commit to
- Study type: Interventional
- Planned participants: 56
- From 31 May 2024 to the primary completion date, 30 Apr 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Patients who hae been on immunotherapy (corticosteroid bolus, IVIg, plasma exchange, endoxan, rituximab or other immunotherapy) fr more than 10 days
- Absolute contraindication to MRI (Pacemaker, cochlear implant, etc.)
Other illness
- History of brain tumor, head trauma, infarction or cerebral hematoma likely to result in altered cerebral carbohydrate metabolism on PET
- Presence of cognitive disorders incompatible with goog cooperation with the PET scan
Other
- Pregnant or breast-feeding woman
- Ventilated intubated patient
- Algic or agitated patient unable to remain immobile in supine position for 30 minutes
- Deprived of liberty or under a protective measure (guardianship or curatorship)
- Patient taking part in other interventional research involving radiopharmaceutical injections
Who the study is looking for
- Age ≥ 18 years old
- Newly diagnosed autoimmune encephalitis based on at least 1 of the 3 following criteria :
- " Definite limbic autoimmune encephalitis " according to 2016 Graus et al. criteria
- " Possible autoimmune encephalitis " according to 2016 Graus et al. criteria AND typical autoantibody detected in serum or CSF
- " Probable or certain paraneoplastic neurological syndrome " according to Graus et al. 2021 criteria (excluding peripheral neurological syndromes)
- Less than 6 months since first neurological symptoms imputable to autoimmune encephalitis
- Affiliated or entitled to a social security system (except AME)
- Obtaining free, written and informed consent (patient or legal representative or the close relative)
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Hospital Pitie Salpetriere Coordinator of this site? Confirm its status | Paris | France | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.