NCT06080568Completed
Human Mitochondrial Stress-driven Obesity Resistance
Energy Balance and Mitochondrial Function in Human Genetic Models of Mitochondrial Stress-mediated Obesity Resistance
Source: ClinicalTrials.gov · Last updated 22 Jun 2025
Brief summary (registry, in English)
The overarching aim of this observational study is to determine alterations in energy balance while exploring the underlying cellular mechanisms in human genetic models of mitochondrial stress. In a case-control design, individuals with pathogenic mitochondrial DNA mutations will be compared to healthy controls matched for sex, age, and physical activity level. Participants will attend a screening visit and an experimental trial including assessments of energy expenditure, appetite sensation, energy intake, and muscle and subcutaneous adipose tissue biopsy samples.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 30 (actual)
- First submitted
- 29 Sept 2023
- Start date
- 20 Oct 2023
- Primary completion date
- 20 Dec 2024
- Lead sponsor
- Copenhagen University Hospital, Rigshospitalet
- Diseases
- Obesity
- NCT number
- NCT06080568
What you commit to
- Study type: Observational
- Participants enrolled: 30
- From 20 Oct 2023 to the primary completion date, 20 Dec 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Use of antiarrhythmic medications or other medications which, in the opinion of the investigators, have the potential to affect outcome measures.
- Current and regular use of antidiabetic medications or other medications which, in the opinion of the investigators, have the potential to affect outcome measures.
Other illness
- Diagnosed severe heart disease, dysregulated thyroid gland conditions, or other dysregulated endocrinopathies, or other conditions which, in the opinion of the investigators, have the potential to affect outcome measures.
- Diagnosed heart disease, symptomatic asthma, liver cirrhosis or -failure, chronic kidney disease, dysregulated thyroid gland conditions or other dysregulated endocrinopathies, or other conditions which, in the opinion of the investigators, have the potential to affect outcome measures
Other
- Pregnancy
- Eligibility criteria for controls
- Daily use of tobacco products
- Excessive alcohol consumption
- Pregnancy
Who the study is looking for
- \- Known mtDNA point mutations
Criteria the registry did not label
- Eligibility criteria for individuals with mitochondrial DNA mutations
Age in the registry: 18 years to - · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Rigshospitalet Coordinator of this site? Confirm its status | Copenhagen | Denmark | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.