NCT06085950Recruiting
Transcranial Ultrasonic Stimulation in Treatment-resistant Depression : an Open-label Pilot Trial
Transcranial Ultrasonic Stimulation in Treatment-resistant Depression: an Open-label Pilot Trial
Source: ClinicalTrials.gov · Last updated 22 Jun 2026
Brief summary (registry, in English)
The primary objective of this study is to optimize the protocol for the TUS administration in patients with TRD while gaining an initial impression of treatment efficacy.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 32 (estimated)
- First submitted
- 12 Sept 2023
- Start date
- 9 May 2023
- Primary completion date
- May 2028
- Lead sponsor
- Centre Hospitalier St Anne
- Diseases
- Depression
- NCT number
- NCT06085950
What you commit to
- Study type: Interventional
- Planned participants: 32
- From 9 May 2023 to the primary completion date, May 2028
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Psychiatric history other than a mood disorder
- Neurological history, including epilepsy and intracerebral calcifications
- History of substance use disorder other than tobacco
- Compulsory psychiatric care
Age
- Women of childbearing age who do not have a negative pregnancy test and are not using contraception
Other
- Contraindication to brain MRI (pacemaker, neurostimulator, injury from metallic shine, …)
- Protected adults, people under legal safeguard
- Pregnant or breastfeeding woman
Who the study is looking for
- Age between 18 and 75 years,
- Diagnosis of major depressive episode (MDE) as part of major depressive disorder as defined by DSM-5 criteria
- Severe MDE (HDRS-17\> 20)
- Drug resistance to at least two well-conducted antidepressant treatment lines
- With stable antidepressant treatment for at least 4 weeks before inclusion
- Benefiting from a social security scheme
- Having given their consent to participate
Age in the registry: 18 years to 75 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| GHU Sainte-Anne Coordinator of this site? Confirm its status | Paris | France | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.