NCT06086366Recruiting
Presynaptic Imaging in Major Depressive Episodes After COVID-19
Source: ClinicalTrials.gov · Last updated 11 Feb 2026
Brief summary (registry, in English)
The goal of this observational study focuses on understanding and addressing a subset of persistent neuropsychiatric symptoms occurring within 3 months after mild to moderate COVID-19 infection (COVID-DNP). COVID-DNP encompasses major depressive episodes (MDE) with or without additional neuropsychiatric symptoms.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 90 (estimated)
- First submitted
- 5 Sept 2023
- Start date
- 22 Aug 2023
- Primary completion date
- 10 Sept 2028
- Lead sponsor
- Centre for Addiction and Mental Health
- Diseases
- Depression, Long COVID and ME/CFS
- NCT number
- NCT06086366
What you commit to
- Study type: Observational
- Planned participants: 90
- From 22 Aug 2023 to the primary completion date, 10 Sept 2028
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Use of antidepressants in the previous month (6 weeks for fluoxetine).
- Use of stimulant medication affecting dopamine release in the previous month
- Use of antipsychotics in the previous month
- Use of medications or herbal products or natural health products with central nervous system effects in past 2 weeks based on self-report
- Use of recreational drugs, including marijuana, in the past two months, based on self-report and verified by the Research Version of Structured Clinical Interview for Diagnostic and Statistical Manual-5 (SCID-5-RV)
- Positive urine drug or cotinine screen at any timepoint during the study
- History of psychotic symptoms secondary to schizophrenia, schizophreniform, bipolar disorder, or brief psychotic disorder prior to COVID-19, based on self-report and verified by the Research Version of Structured Clinical Interview for Diagnostic and Statistical Manual-5 (SCID-5-RV)
- Currently pregnant, based on self-report or positive pregnancy test at any timepoint during the study, in females (in our PET Centre females up to 65 years of age are given a urine pregnancy test prior to every PET scan)
- Presence of metal implant, object or electrical devices that are contraindicated for MRI, based on self-report
Other illness
- History of neurological disease (except migraine, and PASC) based on self-report
- Lifetime diagnosis of severe Substance or Alcohol Use Disorder, or diagnosis of mild to moderate Substance or Alcohol Use Disorder in the past two years, based on self-report and verified by the Research Version of Structured Clinical Interview for Diagnostic and Statistical Manual-5 (SCID-5-RV)
- Current disorders of coagulation, blood or ongoing use of anticoagulant medication, based on self-report
- Severe allergic reaction to alcohol
Other
- Presence of cigarette smoking in the past two months, based on self-report
- Breastfeeding (for females)
- Claustrophobia, based on self-report
- Weight over 400lbs and height over 7ft (requirements for fitting in the scanners and hospital gowns)
Who the study is looking for
- New onset MDE within 3 months after mild or moderate COVID-19, with MDE verified by the research version SCID for DSM 5. See "Positive COVID-19 diagnosis" listed after inclusion/exclusion criteria for a description of how this is determined.
- Age 18 to 75.
- Good general physical health with no active medical conditions based on self-report (except migraine or PASC).
Age in the registry: 18 years to 75 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Centre for Addiction and Mental Health Coordinator of this site? Confirm its status | Toronto | Canada | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.