NCT06088589Completed
Speech-in-noise Perception in Autism and Fragile X
Cortical Mechanisms of Speech in Noise Perception in Autism and Fragile X Syndrome
Source: ClinicalTrials.gov · Last updated 4 Nov 2026
Brief summary (registry, in English)
The goal of this study is to identify which brain regions are active during speech-in-noise perception, as well as how those regions interact. The investigators are studying brain activation during speech-in-noise in autism and controls as well as individuals with Fragile X Syndrome. The main question\[s\] it aims to answer are: 1) How does the brain's response to background noise affect a person's ability to understand speech? 2) Can visual cues improve hearing in background noise? Participants will complete the following: * hearing tests * cognitive and behavioral measures * questionnaires about their symptoms * both passive and active hearing tasks while brain activity is recorded with a neuroimaging cap Results will be compared between individuals with autism with and without Fragile X Syndrome as well as individuals without autism.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 43 (actual)
- First submitted
- 4 Oct 2023
- Start date
- 10 Nov 2023
- Primary completion date
- 14 Apr 2026
- Lead sponsor
- Children's Hospital Medical Center, Cincinnati
- Diseases
- Autism
- NCT number
- NCT06088589
What you commit to
- Study type: Interventional
- Participants enrolled: 43
- From 10 Nov 2023 to the primary completion date, 14 Apr 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- history of premature birth (prior to 36 weeks gestation)
Other
- Hearing loss or uncorrected vision loss
Who the study is looking for
- normal audiograms (PTA ≤ 20 dB HL)
- corrected 20/20 vision (Snellen chart)
- no history of premature birth (prior to 36 weeks gestation)
- no medications known to affect EEG signal
- English as the first language
- Inclusion for the Autism group requires the following:
- 1\) diagnosis of Autism Spectrum Disorder either based on previous ADOS administration and developmental history, or confirmed via ADOS and developmental history
- Inclusion for the Autism + FXS group requires the following:
- Documented PCR/Southern Blot genetic testing confirming full mutation FXS
- Diagnosis of Autism Spectrum Disorder, per Autism group.
- Inclusion for the Typically Developing group requires the following:
- no siblings or parents with an Autism Spectrum Disorder or Fragile X Syndrome
- no current neurological or psychiatric diagnoses
- IQ over 75
Age in the registry: 15 years to 35 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Cincinnati Children's Hospital Coordinator of this site? Confirm its status | Cincinnati | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.