NCT06088914Active, not recruiting
Behavioral and Neural Correlates of Post-Stroke Fatigue
Source: ClinicalTrials.gov · Last updated 7 Aug 2026
Brief summary (registry, in English)
The goal of this phase I/II clinical trial is to determine the behavioral and neural effects of 5-daily transcranial direct current stimulation on post-stroke fatigue. The three aims are: Aim 1: Investigate the behavioral effect of 5 daily sessions of anodal tDCS over the ipsilesional M1 on PSF. Aim 2: Investigate the neurophysiological effect of 5 daily sessions of anodal tDCS over the ipsilesional M1. Aim 3: Determine the relationship between changes in M1 excitability, brain connectivity and changes in PSF. Participants will receive either a real or sham stimulation for 5 consecutive days and fatigue will be assessed before, immediately after and 1-month after the intervention. Fatigue will be assessed using clinical, behavioral, and neurophysiological outcomes.
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 32 (estimated)
- First submitted
- 18 Sept 2023
- Start date
- 15 Dec 2023
- Primary completion date
- 31 Aug 2026
- Lead sponsor
- Texas Woman's University
- Diseases
- Stroke
- NCT number
- NCT06088914
What you commit to
- Study type: Interventional
- Planned participants: 32
- From 15 Dec 2023 to the primary completion date, 31 Aug 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- use of medication which may affect the level of fatigue.
Other
- acute medical problems;
- the presence of any contraindication to tDCS, MRI or TMS;
- the presence of significant depression (score \> 10 on the Patient Health Questionnaire-9);
- significant pain in the upper extremities that interferes with movements; or
Who the study is looking for
- be at least 18 years old;
- have a history of unilateral stroke ≥ 3 months prior to enrollment to ensure stability;
- have an average score ≥ 4 on FSS;
- have some movement capability in the more affected arm (upper extremity Fugl-Meyer(FMUE) ≥ 28) to ensure they can perform the reaching task;
- be able to follow three-step commands.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Texas Woman's University Coordinator of this site? Confirm its status | Dallas | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.