NCT06092437Recruiting
Investigating a Tailored Diuretic Algorithm in Acute Heart Failure Patients
TAILOR-AHF: Randomized Trial Investigating a Tailored Diuretic Algorithm in Acute Heart Failure Patients
Source: ClinicalTrials.gov · Last updated 13 Apr 2026
Brief summary (registry, in English)
Acutely decompensated heart failure (ADHF) is highly prevalent and has a high (financial) burden on the health care system. Treatment often consists of the administration of IV decongestive agents. Adequate dosing is difficult due to varying diuretic resistance and inadequate parameters to evaluate the response. Urine sodium is a promising biomarker to evaluate the diuretic response. It is hypothesized that a tailored, urine sodium guided diuretic algorithm will result in faster and more complete decongestion and therefore lead to better survival (in terms of mortality and heart failure events) while being non-inferior in terms of safety (mainly regression of kidney function).
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 556 (estimated)
- First submitted
- 31 Aug 2023
- Start date
- 27 Feb 2023
- Primary completion date
- 27 Jun 2026
- Lead sponsor
- Zuyderland Medisch Centrum
- Diseases
- Heart failure
- NCT number
- NCT06092437
What you commit to
- Study type: Interventional
- Planned participants: 556
- From 27 Feb 2023 to the primary completion date, 27 Jun 2026
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Patients included in other investigational studies regarding heart failure.
- Presentation with cardiogenic shock or respiratory insufficiency or another reason requiring admission to the intensive care unit upon admission (IC transfer later in the hospitalization is not an exclusion).
Lab values
- Terminal renal insufficiency defined as: dialysis patients or eGFR (estimated glomerular filtration rate) \< 10 mL/min/1.73 m2;
Who the study is looking for
- Age \> 18 years;
- HF (HFrEF, HFmrEF or HFpEF) diagnosed according to the 2021 HF Guidelines of the European Society of Cardiology \[5\];
- Presentation with AHF meaning at least one symptom (dyspnea, orthopnea, or edema) and one sign (rales, peripheral edema, ascites, or pulmonary vascular congestion on chest radiography) of AHF;
- An elevated NT-proBNP \>300pg/ml;
- Requiring the need for iv diuretics.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Amphia Ziekenhuis Coordinator of this site? Confirm its status | Breda | Netherlands | Recruiting |
| Zuyderland MC Coordinator of this site? Confirm its status | Heerlen | Netherlands | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.