NCT06092814Recruiting
tACS to Enhance Language Abilities
Transcranial Alternating Current Stimulation (tACS) to Enhance Language Abilities
Source: ClinicalTrials.gov · Last updated 24 Aug 2026
Brief summary (registry, in English)
The goal of this study is to see if transcranial alternating current stimulation (tACS) can be used to enhance language abilities in people with post-stroke aphasia. Participants will receive real and sham tACS in conjunction with various language tests. Researchers will compare the post-stroke aphasia group with aged matched controls to see if brain response to tACS differs between groups.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 120 (estimated)
- First submitted
- 28 Sept 2023
- Start date
- 12 Jul 2024
- Primary completion date
- 31 Aug 2028
- Lead sponsor
- University of Pennsylvania
- Diseases
- Stroke
- NCT number
- NCT06092814
What you commit to
- Study type: Interventional
- Planned participants: 120
- From 12 Jul 2024 to the primary completion date, 31 Aug 2028
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Current abuse of alcohol or drugs, prescription or otherwise
- Current abuse of alcohol or drugs, prescription or otherwise
Other illness
- Marked naming impairment
- History of significant medical or neurological disorder (other than stroke)
- History of significant or poorly controlled psychiatric disorders
- Diagnosis of a neurodegenerative disease or clinically significant cognitive complaint
- Any unrelated neurologic or physical condition that impairs communication ability
- History of unrelated neurological conditions including but not limited to traumatic brain injury, stroke, or small vessel disease that has resulted in a neurologic deficit
- Any additional neurological condition that would likely reduce the safety of study participation, including central nervous system (CNS) vasculitis, intracranial tumor, intracranial aneurysm, multiple sclerosis or arteriovenous malformations
- A medically unstable cardiopulmonary or metabolic disorder
- Terminal illness associated with survival \<12 months
- Major active psychiatric illness that may interfere with required study procedures or treatments as determined by the enrolling physician
Other
- Inability to understand the nature of the study
- Impaired non-verbal, conceptual processing
- Nursing a child, pregnancy, or intent to become pregnant during the study
- Clinically significant hearing loss
- Contraindications to tACS
- Contraindications to MRI
- Contraindications to tACS
- Contraindications to MRI
Who the study is looking for
- Presence of aphasia
- Suffered a single, left hemisphere stroke
- Stroke ≥6 months old (chronic) at the time of enrollment
- Right-handedness
- Must be able to understand the nature of the study, and give informed consent
Age in the registry: 18 years to 85 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Pennsylvania Coordinator of this site? Confirm its status | Philadelphia | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.