NCT06094816RecruitingPhase 4
Forebrain Electroneutral Transporters in Salt-sensitive Hypertension: an MRI Study
Source: ClinicalTrials.gov · Last updated 24 Mar 2026
Brief summary (registry, in English)
The overall objective of this project is to identify the key salt-sensing regions of the brain and determine the underlying mechanism of sodium sensing. The investigators will assess how the brain responds to an acute increase of salt in the blood using MRI. This will be done during a 30-minute infusion of a saline solution containing 3% salt. One trial will be conducted with a salt sensing channel blocker and one trial without the salt sensing channel blocker. This will help to assess the role of a specific salt sensing channel in the brain. Salt sensitivity of BP will be assessed using 7-day dietary feeding where participants will be given food to consume for 7-days. Comparisons will be made between salt resistant (no change in blood pressure going from low to high salt diets) and salt sensitive adults (a change in blood pressure going from low to high salt diets). The investigators think the changes in MRI will be greater in salt sensitive compared to salt resistant subjects.
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 4
- Study type
- Interventional
- Enrollment
- 120 (estimated)
- First submitted
- 11 Oct 2023
- Start date
- 5 Mar 2024
- Primary completion date
- 1 Jan 2028
- Lead sponsor
- University of Delaware
- Diseases
- High blood pressure
- NCT number
- NCT06094816
What you commit to
- Study type: Interventional · Phase 4
- Planned participants: 120
- From 5 Mar 2024 to the primary completion date, 1 Jan 2028
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Hormone replacement therapy
- Contra-indications to MRI (implants, metal, etc)
Other illness
- History of - cardiovascular, cancer, metabolic, respiratory, renal disease
- Clinically diagnosed psychiatric or neurological disorder
- Psychiatric, neurological, anxiety or depression medications
- Hypertension medications
- Sulfonamide drug allergy
Lab values
- Serum potassium: \< 3.5 mmol/L or \> 5.5 mmol/L
- Major brain injury (concussions do not count)
Age
- Age: \< 40 years or \> 60 years
Other
- Blood pressure: \< 100/60 mmHg or \> 140/90 mmHg
- BMI: \< 18.5 kg/m2 or \> 30 kg/m2
- Abnormal ECG
- Current tobacco or nicotine use
- Pregnant or nursing mothers
- Clinically diagnosed anxiety or depression
- Claustrophobia
Who the study is looking for
- Age: \> 40 years or \< 60 years
- Blood pressure: \> 100/60 mmHg or \< 140/90 mmHg
- BMI: \> 18.5 kg/m2 or \< 35 kg/m2
- Serum potassium: \> 3.5 mmol/L or \< 5.5 mmol/L
- No history of cardiovascular, renal, metabolic, or neurological disease
Age in the registry: 40 years to 60 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Delaware Coordinator of this site? Confirm its status | Newark | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.