NCT06096246Recruiting
Investigation of Cardioversion Versus Therapeutic Ablation for Persistent AF (ORBICA-AF)
Objective Randomised Blinded Investigation of Cardioversion Versus Ablation for Persistent Atrial Fibrillation (ORBICA-AF)
Source: ClinicalTrials.gov · Last updated 22 Sept 2026
Brief summary (registry, in English)
The main aim of the research is to investigate whether patients undergoing pulmonary vein isolation with catheter ablation for persistent atrial fibrillation (AF) will have lower rates of AF recurrence than those treated by DC cardioversion without an ablation procedure.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 208 (estimated)
- First submitted
- 21 Sept 2023
- Start date
- 26 Jul 2024
- Primary completion date
- 26 Jul 2027
- Lead sponsor
- Barts & The London NHS Trust
- Diseases
- Atrial fibrillation
- NCT number
- NCT06096246
What you commit to
- Study type: Interventional
- Planned participants: 208
- From 26 Jul 2024 to the primary completion date, 26 Jul 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Patients in Persistent AF who have had more than one previous cardioversion.
Other illness
- Uncontrolled hypertension
Lab values
- Creatinine clearance (eGFR) \< 30mls/min
Other
- Contraindication or unable to take anticoagulation
- Contraindication for catheter ablation
- BMI \> 40
- Established diagnosis of Hypertrophic cardiomyopathy
Who the study is looking for
- Ability to give informed consent
- Age 18-85 years
- Persistent AF (atrial fibrillation lasting \> 7days) of total continuous duration \<2 years as documented in medical notes.
- Patients being considered for cardioversion.
Age in the registry: 18 years to 85 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Barts Heart Centre Coordinator of this site? Confirm its status | London | United Kingdom | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.