NCT06101862Recruiting
Coronary Computed Tomography Versus Invasive Angiography for Non-ST Elevation Acute Coronary Syndrome
Team-based Interventional Triage in Acute Coronary Syndrome Based on Non-Invasive Computed Tomography Coronary Angiography - a Randomized Trial
Source: ClinicalTrials.gov · Last updated 19 Feb 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
Coronary computed tomography angiography (CCTA) is a widely accepted initial diagnostic test for individuals suspected of having chronic coronary syndromes. However, there is limited evidence supporting its use in the acute setting. So far, no large-scale randomized trial has examined the performance of CCTA as an alternative to invasive coronary angiography (ICA) in individuals with non-ST-segment elevation myocardial infarction (NSTEACS). If CCTA were to replace ICA as a routine procedure for individuals with NSTEACS, it could reduce the risk of complications related to ICA, improve patient comfort, expedite decision-making, and reduce healthcare expenses and interhospital transfers.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 2300 (estimated)
- First submitted
- 28 Sept 2023
- Start date
- 1 Oct 2023
- Primary completion date
- 1 Oct 2026
- Lead sponsor
- Copenhagen University Hospital, Rigshospitalet
- Diseases
- Coronary artery disease
- NCT number
- NCT06101862
What you commit to
- Study type: Interventional
- Planned participants: 2300
- From 1 Oct 2023 to the primary completion date, 1 Oct 2026
- 6 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Prior CCTA or ICA during index admission or within 1 week
- Previously randomized in this trial
Other illness
- History of percutaneous coronary intervention or coronary artery bypass grafting
- Probable type 2 acute myocardial infarction
- Severe valvular heart disease as primary diagnosis or potential need for valve intervention
- History of spontaneous coronary artery dissection
- Known allergy to beta-blockers or contrast agent
Other
- Instability requiring acute or emergent ICA
- Estimated glomerular filtration rate \< 30 mL/min/1.73m2
- Expected poor quality of the CCTA
- Pregnant or nursing
Who the study is looking for
- Admitted with non-ST-segment elevation myocardial infarction or unstable angina pectoris and an indication for subacute ICA
- Elevated troponin or ischemic electrocardiographic changes
- Written informed consent
Sex: All · Does not accept healthy volunteers
Sites (6)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Bispebjerg Hospital Coordinator of this site? Confirm its status | Bispebjerg | Denmark | Recruiting |
| Herlev and Gentofte Hospital Coordinator of this site? Confirm its status | Copenhagen | Denmark | Recruiting |
| Zealand University Hospital Coordinator of this site? Confirm its status | Copenhagen | Denmark | Recruiting |
| Rigshospitalet Coordinator of this site? Confirm its status | Copenhagen | Denmark | Recruiting |
| North Zealand Hospital Coordinator of this site? Confirm its status | Hillerød | Denmark | Recruiting |
| Hvidovre Hospital Coordinator of this site? Confirm its status | Hvidovre | Denmark | Recruiting |
Related publications
This page is information, not medical advice. Discuss any trial with your doctor.