The Effect of a Low-fat Vegan Dietary Intervention on Intracellular Lipid, Insulin Sensitivity, and Glycemic Control in Type 2 Diabetes

Prior treatment

• Diabetes mellitus, type 1 and/or treatment with insulin or sulfonylureas
• Use of recreational drugs in the past 6 months
• Use within the preceding six months of medications that affect appetite or body weight, such as estrogens or other hormones, thyroid medications, systemic steroids, antidepressants (tricyclics, monoamine oxidase inhibitors, selective serotonin reuptake inhibitors), antipsychotics, lithium, anticonvulsants, appetite suppressants or other weight-loss drugs, herbs for weight loss or mood, St. John's wort, ephedra, beta-blockers
• Inability to maintain current medication regimen

Other illness

• Metal implants, such as a cardiac pacemaker or an aneurysm clip
• History of any endocrine condition that would affect body weight, such as thyroid disease, pituitary abnormality, or Cushing's syndrome
• Alcohol consumption of more than 2 drinks per day or the equivalent, episodic increased drinking (e.g., more than 2 drinks per day on weekends), or a history of alcohol abuse or dependency followed by any current use
• Unstable medical or psychiatric illness
• Evidence of an eating disorder

Other

• Smoking during the past six months
• Pregnancy or intention to become pregnant during the study period
• Likely to be disruptive in group sessions
• Already following a low-fat, vegan diet
• Lack of English fluency
• Inability or unwillingness to participate in all components of the study
• Intention to follow another weight-loss method during the trial

• Men and women with type 2 diabetes treated by diet and/or oral hypoglycemic agents other than sulfonylureas
• Age ≥18 years
• Body mass index 26-40 kg/m2
• Medications (antidiabetic, antihypertensive, and lipid-lowering) have been stable for the past 3 months
• HbA1c between 6.0-10.5% (42-91 mmol/mol)