NCT06108206Active, not recruiting
Adaptive Radiotherapy and MRIs Based on Patients With Newly Diagnosed High-Grade Glioma
Adaptive Radiotherapy Based on Multi-Parametric Diffusion- and Perfusion-weighted Magnetic Resonance Imaging in Patients With Newly Diagnosed High-Grade Glioma
Source: ClinicalTrials.gov · Last updated 19 Aug 2026
Brief summary (registry, in English)
The purpose of this study is to find out if performing additional Magnetic Resonance Image (MRI) scans of the subjects' brain during each week of the radiation treatment of their high-grade glioma will help improve the radiation treatment.
- Status (registry)
- Active, not recruiting
- Study type
- Observational
- Enrollment
- 20 (estimated)
- First submitted
- 23 Oct 2023
- Start date
- 30 Jan 2024
- Primary completion date
- Dec 2026
- Lead sponsor
- Columbia University
- Diseases
- Glioblastoma
- NCT number
- NCT06108206
What you commit to
- Study type: Observational
- Planned participants: 20
- From 30 Jan 2024 to the primary completion date, Dec 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Prior therapy for tumor except for biopsy or resection, including prior radiotherapy to the brain.
Other illness
- Clinical or radiological evidence of metastatic disease outside the brain
- Prior malignancy (except non-melanomatous skin cancer) unless disease free for a minimum of 2 years
Who the study is looking for
- Histopathologically proven diagnosis of glioblastoma, anaplastic astrocytoma, or anaplastic oligodendroglioma
- History and physical examination within 28 days prior to enrollment
- Karnofsky performance status 70 or greater
- Age 18 years or greater
- Negative pregnancy test for females of childbearing potential before 1st research MRI, performed in accordance to institutional guidelines.
- Plan to receive standard of care 59.4-60 Gy in 30-33 fractions of radiotherapy. Glioblastoma patients over 65 year-old can receive standard of care hypofractionated radiotherapy including 40 Gy in 15 fractions.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Columbia University Irving Medical Center/NYPH Coordinator of this site? Confirm its status | New York | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.