NCT06111105Recruiting
GUIDE.MRD-01-CRC: Clinical Validation and Benchmarking of Top Performing ctDNA Diagnostics - Colorectal Cancer
GUIding Multi-moDal thErapies Against MRD by Liquid Biopsies in Colorectal Cancer - GUIDE.MRD-01-CRC
Source: ClinicalTrials.gov · Last updated 4 May 2026
Brief summary (registry, in English)
Improving personalized cancer treatments and finding the best strategies to treat each patient relies on using new diagnostic technologies. Currently, for colorectal cancer, the methods used to decide who gets additional post-surgery treatment are suboptimal. Some patients get too much treatment, while others do not get enough. There is a new way to explore if there is any cancer left in a patient's body using circulating tumor DNA (ctDNA) detected in blood samples. This can help decide who needs more treatment after surgery. Even though many tests have been developed, it has yet to be determined which test performs best at relevant time points. The GUIDE.MRD consortium is a group of experts, including scientists, technology, and pharmaceutical companies. The consortium is working on creating a reliable standard for the ctDNA tests, validating their clinical utility, and collecting data to help decide on the best treatment for each patient. GUIDE.MRD-01-CRC is a part of the GUIDE.MRD project.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 590 (estimated)
- First submitted
- 26 Oct 2023
- Start date
- 1 Aug 2023
- Primary completion date
- 31 Jul 2026
- Lead sponsor
- Claus Lindbjerg Andersen
- Diseases
- Colorectal cancer
- NCT number
- NCT06111105
What you commit to
- Study type: Observational
- Planned participants: 590
- From 1 Aug 2023 to the primary completion date, 31 Jul 2026
- 15 sites in 5 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Not treated with adjuvant chemotherapy despite indication (incomplete treatment not included)
- Treated with neoadjuvant chemo-radiation therapy
Other illness
- Hereditary colorectal cancer linked to familial colonic polyposis or Lynch syndrome
- Inflammatory bowel disease (Crohn's disease or ulcerative colitis)
- Synchronous colorectal and non-colorectal cancer diagnosed per operative (except skin cancer other than melanoma)
- Other cancers (excluding colorectal cancer or skin cancer other than melanoma) within 3 years from eligibility screening
- Patients who are unlikely to comply with the protocol (e.g. uncooperative attitude), inability to return for subsequent visits) and/or otherwise considered by the Investigator to be unlikely to complete the study
- Colorectal cancer liver metastasis
- Other cancer within the last 5 years
Other
- Verified distant metastases
- No tissue sample available for the project, or tumor content in the tissue sample is \<20%
- Liver cirrhosis
- Extrahepatic metastases
- Intervention not performed with curative intent
- No tissue available from CRLM or primary tumor
Who the study is looking for
- Colorectal cancer, UICC stage III
- Has received curative-intent resection and is a candidate for adjuvant chemotherapy
- Patient able to understand and sign written informed consent
- Colorectal cancer liver metastasis
- Planned for curative-intent treatment
- Performance status 0-1
Criteria the registry did not label
- Colorectal cancer stage III
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (15)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Abteilung für Onkologie, Medizinische Universität Graz Coordinator of this site? Confirm its status | Graz | Austria | Recruiting |
| Ordenskrankenhaus Graz Mitte Coordinator of this site? Confirm its status | Graz | Austria | Recruiting |
| Department of General-, Visceral- and Thoracic Surgery, University Medical Center Hamburg-Eppendorf Coordinator of this site? Confirm its status | Hamburg | Germany | Recruiting |
| Universitätsklinikum Hamburg-Eppendorf Coordinator of this site? Confirm its status | Hamburg | Germany | Recruiting |
| Aalborg University Hospital Coordinator of this site? Confirm its status | Aalborg | Denmark | Recruiting |
| Aarhus University Hospital Coordinator of this site? Confirm its status | Aarhus | Denmark | Recruiting |
| Bispebjerg Hospital Coordinator of this site? Confirm its status | Copenhagen | Denmark | Recruiting |
| Herlev Hospital Coordinator of this site? Confirm its status | Herlev | Denmark | Not yet recruiting |
| Gødstrup Hospital Coordinator of this site? Confirm its status | Herning | Denmark | Recruiting |
| Regional Hospital Horsens Coordinator of this site? Confirm its status | Horsens | Denmark | Recruiting |
| Odense University Hospital Coordinator of this site? Confirm its status | Odense | Denmark | Recruiting |
| Regional Hospital Randers Coordinator of this site? Confirm its status | Randers | Denmark | Recruiting |
| Regional Hospital Viborg Coordinator of this site? Confirm its status | Viborg | Denmark | Recruiting |
| LCCRH (Laboratoire Cellules Circulantes Rares Humaines) - CHU de Montpellier Coordinator of this site? Confirm its status | Montpellier | France | Recruiting |
| Karolinska University Hospital Coordinator of this site? Confirm its status | Huddinge | Sweden | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.