NCT06113510Recruiting
Non-invasive Coronary Thrombus Imaging to Define These Cause of Acute Myocardial Infarction
Non-invasive Coronary Thrombus Imaging to Define the Cause of Acute Myocardial Infarction
Source: ClinicalTrials.gov · Last updated 14 Sept 2026
Brief summary (registry, in English)
We now have very sensitive blood tests that can pick up damage to the heart and find patients who have had a heart attack. However, whilst this is welcome, it does not identify what causes the heart attack and can sometimes pick up other conditions that cause a strain on the heart. The classic cause of a heart attack is when a blood clot forms on fatty deposits within the heart arteries. This leads to treating patients with blood thinning medication, and this is very effective and saves lives. However, many apparent heart attacks are not caused by blood clots and some may be caused by blood clots but pass unrecognised. In this proposal, we will test an exciting new imaging test that can 'see' from outside the body whether there is a blood clot in the heart arteries. This could provide a major new way of assessing patients to ensure they get the right diagnosis and the right treatment. This could ultimately improve the outcomes of or patients with heart attacks. We will recruit 80 patients in total who have recently been diagnosed with a heart attack from the cardiology department at the Royal Infirmary of Edinburgh. The research team will review patient's medical records to determine eligibility for the study. The research study involves participants undertaking the following research procedures and assessments: 1. A combined Positron Emission Tomography and Computed Tomography (PET-CT) scan of the heart 2. Ultrasound scan of the heart (Echocardiogram) 3. MRI scan of the heart 4. A blood test - a total of up to four tablespoons (60 mL) of blood will be taken for immediate testing and the remaining blood will be stored for future ethically approved studies 5. A follow up questionnaire 6 -12 months following the heart attack
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 80 (estimated)
- First submitted
- 27 Oct 2023
- Start date
- 6 Jan 2025
- Primary completion date
- Aug 2028
- Lead sponsor
- University of Edinburgh
- Diseases
- Coronary artery disease
- NCT number
- NCT06113510
What you commit to
- Study type: Observational
- Planned participants: 80
- From 6 Jan 2025 to the primary completion date, Aug 2028
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Renal failure (estimated glomerular filtration rate \<30 mL/min/1.73 m2)
- Known allergy or contraindication to iodinated contrast or radiotracer
Age
- \<18 years of age
Other
- Takatsubo cardiomyopathy
- Myocarditis
- Woman of child-bearing potential who are pregnant or breastfeeding
- Patients unable to tolerate the supine position
- Patients unable to provide informed consent
Who the study is looking for
- Males and females ≥ 18 years of age
- Clinical presentation of chest pain, ST-segment deviation within a coronary artery territory on the electrocardiogram, raised cardiac troponin and non-obstructive coronary arteries on invasive coronary angiography as per international societal diagnostic criteria
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Royal Infirmary of Edinburgh Coordinator of this site? Confirm its status | Edinburgh | United Kingdom | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.