NCT06116526TerminatedPhase 4
Dupilumab De-escalation in Pediatric Atopic Dermatitis
Dupilumab De-escalation in Pediatric Atopic Dermatitis: A Pilot Trial
Source: ClinicalTrials.gov · Last updated 3 Nov 2026
Reason given: Poor accrual
Brief summary (registry, in English)
This is a pilot investigator-blinded, randomized clinical trial to assess the feasibility of dupilumab treatment discontinuation or dose-reduction in children aged 1-17 years who have achieved sustained atopic dermatitis (AD) control on dupilumab.
- Status (registry)
- Terminated
- Phase (registry)
- Phase 4
- Study type
- Interventional
- Enrollment
- 1 (actual)
- First submitted
- 30 Oct 2023
- Start date
- 1 Apr 2024
- Primary completion date
- 18 Jul 2026
- Lead sponsor
- Johns Hopkins University
- Diseases
- Atopic dermatitis (eczema)
- NCT number
- NCT06116526
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Taking concurrent systemic medication for atopic dermatitis (e.g., methotrexate, cyclosporine, tralokinumab, abrocitinib, upadacitinib, systemic corticosteroids)
- Using concurrent phototherapy for atopic dermatitis
- Has used an investigational drug within 90 days or plan to use an investigational drug during the study period
Other
- Taking dupilumab for a clinical indication other than atopic dermatitis (such as asthma or eosinophilic esophagitis)
- Poor control of atopic dermatitis
- Poor control of asthma or eosinophilic esophagitis
- Does not have health insurance or will lose health insurance during the study period
Who the study is looking for
- Aged 1 to <18 years old, either sex, any race or ethnicity
- Provide signed informed consent by parent or legal guardian and informed assent if applicable
- Has a physician confirmed diagnosis of atopic dermatitis
- Has received dupilumab for at least 12 months for the treatment of atopic dermatitis
- Has had well-controlled atopic dermatitis on dupilumab within last 6 months (defined as POEM<=7, EASI<=7, or IGA<=2)
- Able to speak English
- Able and willing to adhere to all study procedures
Age in the registry: 1 year to 17 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Johns Hopkins Univerisity | Baltimore | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.