Clinical Validation of Freenome Multiomics Blood Test for Lung Cancer Screening

Prior treatment

• History of any malignancy within prior 5 years of enrollment (except for non- melanoma skin cancer)
• Screened for lung cancer or having chest CT scan 12 months before enrollment
• Received a blood transfusion in the 30 days preceding enrollment
• Participated or currently participating in a clinical research study in which an experimental medication has been administered during the 60 days preceding enrollment

Other illness

• Any active therapy for cancer, including but not limited to surgery, chemotherapy, biologic therapy, immunotherapy, and/or radiation therapy at the time of enrollment
• History of organ, tissue, and bone marrow transplantation
• Having signs and symptoms of lung cancer such as hemoptysis, superior vena cava syndrome, Cushing syndrome, and Pancoast syndrome
• Any condition that in the opinion of the Investigator should not be enrolled in the study

Other

• Known to be pregnant
• Participated or currently participating in another Freenome-sponsored clinical study

• Age 50 years or older within 30 days of enrollment
• Current or former smokers with a cumulative smoking history of ≥ 20 pack-year
• Able to comprehend and willing to sign and date the informed consent and HIPAA authorization documents