NCT06123377Recruiting
Angiogenic Factors in the Conservative Management of Gestational Hypertension
Use of Angiogenic Factors in the Conservative Management of Gestational Hypertension. Prospective, Randomised, Controlled Study.
Source: ClinicalTrials.gov · Last updated 26 Aug 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
Hypertensive disorders of pregnancy (HPT) are an important cause of maternal-feto-neonatal morbidity and mortality, being one of the three leading causes of maternal death in our country and in developing countries. The only cure for THE is termination of pregnancy, which ends up being a decision in which gestational age and maternal risks must be balanced. Angiogenic factors have come to occupy an indispensable place in the arsenal of tools that can be used to separate the patient with a high likelihood of complications from those in whom prolongation of pregnancy could represent an important neonatal benefit. One of the most controversial scenarios is gestational hypertension, a group of hypertensive disorders considered the mildest form of the pre-eclamptic spectrum, where current recommendations indicate termination of pregnancy at 37 weeks. However, the decision is based on outdated guidelines developed at a time when angiogenic factors were just beginning to be known. The purpose of the study is to use angiogenic factors as a guide to decide the most appropriate gestational age for termination of pregnancy in patients diagnosed with gestational hypertension.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 150 (estimated)
- First submitted
- 29 Oct 2023
- Start date
- 1 Jun 2024
- Primary completion date
- 15 Aug 2026
- Lead sponsor
- Saint Thomas Hospital, Panama
- Diseases
- High blood pressure
- NCT number
- NCT06123377
What you commit to
- Study type: Interventional
- Planned participants: 150
- From 1 Jun 2024 to the primary completion date, 15 Aug 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Previous cesarean section (3 or more)
Other illness
- Neurological conditions
- Chronic renal disease
- Heart disease
Other
- Multiple gestation
- Maternal vasculitis
- Purpura
- Index sFlt-1/PIGF of 34 or more
Who the study is looking for
- Pregnant women between 24 and 40 weeks of gestation.
- Diagnosis of Gestational Hypertension based on ACOG criteria
- index sFlt-1/PIGF equal or below 33
Age in the registry: 18 years to - · Sex: Female · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Hospital Santo Tomás Coordinator of this site? Confirm its status | Panama City | Panama | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.