NCT06128525Completed
Prostate Resection After Microwave Ablation (PRAMA)
PRAMA (Prostate Resection After Microwave Ablation) MRI/Ultrasound Fusion Guided Transperineal Targeted Microwave Ablation for Prostate Cancer
Source: ClinicalTrials.gov · Last updated 28 Nov 2025
Brief summary (registry, in English)
This phase I trial tests the safety of magnetic resonance imaging (MRI)/ ultrasound (US) fusion guided transperineal targeted microwave ablation (TMA) before a radical prostatectomy (RP) and how well it works in treating patients with prostate cancer. Prostate cancer is the second most common cancer in men and most will never become aggressive. Despite this, most men choose to undergo treatment which may include surgery. Removing the prostate gland and sometimes the lymph nodes (radical prostatectomy) is an invasive treatment for prostate cancer that can have a significant negative on quality of life. TMA is a less invasive procedure that uses high temperatures given through the skin between the scrotum and the rectum (transperineal). Using focused high energy and heating tumor cells to several degrees above normal body temperature may kill them without affecting the surrounding tissue. Using multiparametric (mp)MRI/US to create a 3-dimensional picture of the tumor may help in planning and preventing damage to healthy tissue. Giving MRI/US fusion guided transperineal TMA prior to radical prostatectomy may kill tumor cells, and may improve the quality of life in patients with prostate cancer.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 1 (actual)
- First submitted
- 8 Sept 2023
- Start date
- 10 Nov 2023
- Primary completion date
- 26 Aug 2025
- Lead sponsor
- University of Southern California
- Diseases
- Prostate cancer
- NCT number
- NCT06128525
What you commit to
- Study type: Interventional
- Participants enrolled: 1
- From 10 Nov 2023 to the primary completion date, 26 Aug 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Past medical history of prostate surgery
- Past medical history of radiotherapy or pelvic trauma
- Past treatment for prostate cancer (PCa) (radiation, ablation, androgen deprivation therapy \[ADT\], chemotherapy)
Who the study is looking for
- Adult men diagnosed with prostate cancer and undergoing prostatectomy as treatment of choice
- Index lesion visible on multiparametric MRI confirmed by targeted biopsies using KOELIS Trinity (registered trademark)
- Patient suitable for intravenous (IV) sedation or general anesthesia and TMA
- Free, informed, and written consent, dated and signed before the enrollment and before any exam required by the trial
Age in the registry: 18 years to - · Sex: Male · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| USC / Norris Comprehensive Cancer Center Coordinator of this site? Confirm its status | Los Angeles | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.