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NCT06128551RecruitingPhase 1/2

Study of Elironrasib and Daraxonrasib as Monotherapies and Combination Therapy in Participants With Advanced KRAS G12C Mutant Solid Tumors

Phase 1b/2, Multicenter, Open-label, Dose Escalation and Dose Expansion Study of Elironrasib and Daraxonrasib as Monotherapies and Combination Therapy in Patients With Advanced KRAS G12C-Mutated Solid Tumors

Source: ClinicalTrials.gov · Last updated 22 Sept 2026

Brief summary (registry, in English)

This study is to evaluate the safety, tolerability, and PK profiles of Elironrasib and Daraxonrasib as monotherapies and combination therapy in patients with KRAS G12C-mutated solid tumors.

Status (registry)
Recruiting
Phase (registry)
Phase 1/2
Study type
Interventional
Enrollment
534 (estimated)
First submitted
7 Nov 2023
Start date
14 Nov 2023
Primary completion date
Dec 2028
Lead sponsor
Revolution Medicines, Inc.
NCT number
NCT06128551

What you commit to

  • Study type: Interventional · Phase 1/2
  • Planned participants: 534
  • From 14 Nov 2023 to the primary completion date, Dec 2028
  • 56 sites in 7 countries
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Prior treatment

  • Major surgical procedures within 28 days or non-study related minor procedures within 7 days of treatment

Other illness

  • Known impairment of GI function that would alter the absorption

Other

  • Primary central nervous system (CNS) tumors
  • Active brain metastases

Who the study is looking for

  • 18 years of age
  • Histology: pathologically documented, KRAS G12C-mutated, advanced or metastatic solid tumors not amendable to curative therapy
    • Phase 1b Dose Escalation: solid tumors, previously treated
    • Phase 1b Dose Expansion and Phase 2:
    • NSCLC, previously treated with immunotherapy, chemotherapy, and KRAS G12C (OFF) inhibitors ii. Solid tumors, previously treated, naïve to KRAS G12C (OFF) inhibitors.
  • ECOG performance status 0 or 1
  • Adequate organ function

Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (56)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
Universitäts Klinikum Köln
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CologneGermanyRecruiting
Klinikum Esslingen GmbH
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Esslingen am NeckarGermanyRecruiting
Krankenhaus Bethanien Moers
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MoersGermanyRecruiting
Klinkum Nurnberg Paracelsus Medical Unviersity
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NurembergGermanyRecruiting
START Barcelona Hospital HM Nou Delfos
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BarcelonaSpainRecruiting
Institut Catala d'Oncologia Hospital
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BarcelonaSpainRecruiting
Hospital Universitario 12 de Octubre
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MadridSpainRecruiting
NEXT Oncology - Quirónsalud Madrid University Hospital
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MadridSpainRecruiting
University Clinic of Navarra
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MadridSpainRecruiting
START Madrid
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MadridSpainRecruiting
Fundacion MD Anderson Cancer Center
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MadridSpainRecruiting
University Clinic of Navarra
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PamplonaSpainRecruiting
Hospital Universitario Virgen Macarena
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SevilleSpainRecruiting
La Fe University and Polytechnic Hospital
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ValenciaSpainRecruiting
Hospital Universitario Miguel Servet
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ZaragozaSpainRecruiting
West Cancer Institute
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AngersFranceRecruiting
Institut Bergonie
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BordeauxFranceRecruiting
Hospital Louise Pradel
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BronFranceRecruiting
Oscar Lambret Center of Lillle
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LilleFranceRecruiting
Centre Leon Berard
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LyonFranceRecruiting
Cancer Institute of Montpellier
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MontpellierFranceRecruiting
CHU Nantes
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NantesFranceRecruiting
Institute of Cancer of Strasbourg
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StrasbourgFranceWithdrawn
Department of Medical Oncology - Azienda Ospedaliero Uniersitaria delle Marche
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AnconaItalyRecruiting
Centro di Riferimento Oncologico
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AvianoItalyRecruiting
Institute Romagnolo per lo Studio Tumori
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MeldolaItalyRecruiting
Niguarda Cancer Center
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MilanItalyRecruiting
Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale"
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NaplesItalyRecruiting
San Luigi Hospital
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OrbassanoItalyRecruiting
AUSL Romagna - S.M. delle Croci Hospital
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RavennaItalyRecruiting
Centro Ricerche Cliniche di Verona Srl
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VeronaItalyRecruiting
Netherlands Cancer Institute-Antoni van Leeuwenhoek
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AmsterdamNetherlandsRecruiting
Pan American Center for Oncology Trials
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San JuanPuerto RicoRecruiting
University of Colorado Cancer Center
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AuroraUnited StatesRecruiting
Dana-Farber Cancer Institute
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BostonUnited StatesRecruiting
Mary Crowley Cancer Research
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DallasUnited StatesCompleted
Henry Ford Cancer
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DetroitUnited StatesWithdrawn
City of Hope
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DuarteUnited StatesWithdrawn
NEXT Oncology- Virginia
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FairfaxUnited StatesRecruiting
START | Midwest
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Grand RapidsUnited StatesRecruiting
MD Anderson
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HoustonUnited StatesRecruiting
Community Health Network
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IndianapolisUnited StatesRecruiting
NEXT Dallas
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IrvingUnited StatesRecruiting
Sarah Cannon Research Institue
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NashvilleUnited StatesRecruiting
Columbia University
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New YorkUnited StatesRecruiting
NYU Langone Health
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New YorkUnited StatesRecruiting
Memorial Sloan-Kettering Cancer Center
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New YorkUnited StatesRecruiting
University of Oklahoma
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Oklahoma CityUnited StatesRecruiting
UC Irvine Health
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OrangeUnited StatesRecruiting
Allegheny Health Network
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PittsburghUnited StatesRecruiting
UC Davis Comprehensive Cancer Center
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SacramentoUnited StatesRecruiting
START Texas
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San AntonioUnited StatesRecruiting
NEXT Oncology San Antonio
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San AntonioUnited StatesRecruiting
Florida Cancer Specialists
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SarasotaUnited StatesRecruiting
Stanford Cancer Institute
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StanfordUnited StatesRecruiting
Moffitt Cancer Center and Research Institute
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TampaUnited StatesRecruiting

This page is information, not medical advice. Discuss any trial with your doctor.