NCT06128824Active, not recruiting
High Frequency Imaging in Cerebral Amyloid Angiopathy
High Frequency Imaging in Patients With Cerebral Amyloid Angiopathy
Source: ClinicalTrials.gov · Last updated 12 Sept 2025
Brief summary (registry, in English)
Cerebral amyloid angiopathy (CAA), caused by amyloid beta depositions in the walls of small cerebral vessels, is remarkably common in the elderly. Its major clinical consequences include intracerebral hemorrhages (ICH) typically in lobar location, functional dependence (disability) and cognitive impairment. Cortical superficial siderosis (cSS) is a common finding in CAA patients and can even be the only magnetic resonance imaging sign of CAA. cSS is of high prognostic relevance regarding future intracerebral haemorrhage and disability. Previous studies suggest that cSS is caused by recurrent focal subarachnoid hemorrhages (fSAH). However, the exact mechanisms and the temporal dynamics of this highly relevant imaging finding are largely unknown. In addition to hemorrhagic manifestations, such as cSS, CAA patients also show ischemic lesions. Of particular interest are acute ischemic lesions as detected by diffusion imaging, which seem to be highly prevalent. Since haemorrhagic and ischemic lesions require fundamentally different therapeutic strategies, understanding the relevance and interplay of both lesion types is highly important for clinical decision making. The HIFI-CAA cohort study aims to provide novel insights into cSS, acute ischemic lesions and other relevant brain alterations in CAA through high-frequency (monthly) serial magnetic resonance imaging.
- Status (registry)
- Active, not recruiting
- Study type
- Observational
- Enrollment
- 75 (estimated)
- First submitted
- 26 Oct 2023
- Start date
- 19 Mar 2019
- Primary completion date
- 31 May 2026
- Lead sponsor
- Martin Dichgans
- NCT number
- NCT06128824
What you commit to
- Study type: Observational
- Planned participants: 75
- From 19 Mar 2019 to the primary completion date, 31 May 2026
- 3 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Severe medical condition with expected life expectancy \<1 year
Other
- Unwillingness to participate in high-frequency (monthly) follow-up
- Contraindications for MRI (following local guidelines of the respective study center)
Who the study is looking for
- Probable CAA according to the modified Boston criteria with evidence of
- cSS or fSAH
- lobar ICH survivors without cSS or fSAH
- Absence of ICH or microbleed in deep locations (basal ganglia, thalamus, brain stem)
- Absence of infratentorial siderosis or infratentorial SAH
- MR-/CT-/DS-angiography without evidence of cerebral aneurysm, AVM, AV-fistula or other possible etiology for the observed haemorrhagic manifestations
- No history of head trauma resulting in loss of consciousness or radiologically visible traumatic brain injury
- Written informed consent by patient herself/himself prior to study enrolment
Age in the registry: 50 years to - · Sex: All · Does not accept healthy volunteers
Sites (3)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| DZNE/Bonn - Klinik und Poliklinik für Neurologie, Universitätsklinikum Bonn Coordinator of this site? Confirm its status | Bonn | Germany | Unknown status |
| DZNE/Magdeburg - Universitätsklinikum Magdeburg Coordinator of this site? Confirm its status | Magdeburg | Germany | Unknown status |
| Insitute for Stroke and Dementia Research Coordinator of this site? Confirm its status | Munich | Germany | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.