NCT06131437CompletedPhase 3
A Research Study to See How Well CagriSema Compared to Tirzepatide Helps People With Obesity Lose Weight
Efficacy and Safety of Cagrilintide 2.4 mg s.c. in Combination With Semaglutide 2.4 mg s.c. (CagriSema s.c. 2.4 mg/2.4 mg) Once-weekly Compared to Tirzepatide 15 mg s.c. Once-weekly in Participants With Obesity
Source: ClinicalTrials.gov · Last updated 6 Feb 2026
Brief summary (registry, in English)
This study will look at how well CagriSema compared to Tirzepatide helps people lower their body weight. CagriSema is a new investigational medicine developed by Novo Nordisk that combines Cagrilintide and Semaglutide. CagriSema is not yet being prescribed by doctors. Participant will get injections once a week throughout the treatment period. Participant will inject the study medicine under the skin with a pen injector in the thigh, stomach, or upper arm. After a first low dose, the study medicine will be gradually increased until reaching the planned dose (2.4 mg CagriSema or 15 mg Tirzepatide). The study will last for about one and a half year for each participant.
- Status (registry)
- Completed
- Phase (registry)
- Phase 3
- Study type
- Interventional
- Enrollment
- 809 (actual)
- First submitted
- 9 Nov 2023
- Start date
- 27 Nov 2023
- Primary completion date
- 8 Dec 2025
- Lead sponsor
- Novo Nordisk A/S
- Diseases
- Obesity
- NCT number
- NCT06131437
What you commit to
- Study type: Interventional · Phase 3
- Participants enrolled: 809
- From 27 Nov 2023 to the primary completion date, 8 Dec 2025
- 46 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- History of type 1 or type 2 diabetes mellitus
Lab values
- Glycated haemoglobin (HbA1c) ≥ 6.5 % (48 millimoles per mole \[mmol/mol\]) as measured by the central laboratory at screening
Who the study is looking for
- Male or female
- Age 18 years or above at the time of signing the informed consent
- Body mass index (BMI) of ≥ 30.0 kilogram per square meter (kg/m\^2)
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (46)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Amarillo Med Spec LLP Coordinator of this site? Confirm its status | Amarillo | United States | Unknown status |
| Washington Cntr Weight Mgmt Coordinator of this site? Confirm its status | Arlington | United States | Unknown status |
| Univ of Colorado at Denver Coordinator of this site? Confirm its status | Aurora | United States | Unknown status |
| Elligo Clin Res Centre Coordinator of this site? Confirm its status | Austin | United States | Unknown status |
| UT Health University of Texas Coordinator of this site? Confirm its status | Bellaire | United States | Unknown status |
| Univ of Alabama Birmingham Coordinator of this site? Confirm its status | Birmingham | United States | Unknown status |
| Holston Medical Group_Bristol Coordinator of this site? Confirm its status | Bristol | United States | Unknown status |
| Northern Pines Hlth Ctr, PC Coordinator of this site? Confirm its status | Buckley | United States | Unknown status |
| University of North Carolina Coordinator of this site? Confirm its status | Chapel Hill | United States | Unknown status |
| Medical University of South Carolina Coordinator of this site? Confirm its status | Charleston | United States | Unknown status |
| Great Lakes Clinical Trials Coordinator of this site? Confirm its status | Chicago | United States | Unknown status |
| StudyMetrix Research, LLC Coordinator of this site? Confirm its status | City of Saint Peters | United States | Unknown status |
| Hope Clin Res & Wellness Coordinator of this site? Confirm its status | Conyers | United States | Unknown status |
| FDRC Coordinator of this site? Confirm its status | Costa Mesa | United States | Unknown status |
| Clinical Res Collaborative Coordinator of this site? Confirm its status | Cumberland | United States | Unknown status |
| Baylr Sctt White Rs Inst, Endo Coordinator of this site? Confirm its status | Dallas | United States | Unknown status |
| UT Southwestern Medical Center-CRU Coordinator of this site? Confirm its status | Dallas | United States | Unknown status |
| Velocity Clin Res, Dallas Coordinator of this site? Confirm its status | Dallas | United States | Unknown status |
| Northeast Research Institute Coordinator of this site? Confirm its status | Fleming Island | United States | Unknown status |
| PharmQuest Life Sciences LLC Coordinator of this site? Confirm its status | Greensboro | United States | Unknown status |
| Medication Mgmnt, LLC_Grnsboro Coordinator of this site? Confirm its status | Greensboro | United States | Unknown status |
| East West Med Res Inst Coordinator of this site? Confirm its status | Honolulu | United States | Unknown status |
| Midwest Inst For Clin Res Coordinator of this site? Confirm its status | Indianapolis | United States | Unknown status |
| Jacksonville Ctr for Clin Res Coordinator of this site? Confirm its status | Jacksonville | United States | Unknown status |
| Holston Medical Group. Coordinator of this site? Confirm its status | Kingsport | United States | Unknown status |
| DCOL Ctr for Clin Res Coordinator of this site? Confirm its status | Longview | United States | Unknown status |
| South Broward Research LLC Coordinator of this site? Confirm its status | Miramar | United States | Unknown status |
| Chambliss Clinical Trials, LLC Coordinator of this site? Confirm its status | Montgomery | United States | Unknown status |
| Yale University School Of Medicine Coordinator of this site? Confirm its status | New Haven | United States | Unknown status |
| Health Res of Hampton Roads Coordinator of this site? Confirm its status | Newport News | United States | Unknown status |
| Comprehensive Weight Ctrl Prog Coordinator of this site? Confirm its status | New York | United States | Unknown status |
| Lynn Institute of Norman Coordinator of this site? Confirm its status | Norman | United States | Unknown status |
| Coastal Carolina Res Ctr Coordinator of this site? Confirm its status | North Charleston | United States | Unknown status |
| Capital Clin Res Ctr,LLC Coordinator of this site? Confirm its status | Olympia | United States | Unknown status |
| The University of Penn Center Coordinator of this site? Confirm its status | Philadelphia | United States | Unknown status |
| Accellacare_NC Coordinator of this site? Confirm its status | Raleigh | United States | Unknown status |
| Rainier Clin Res Ctr Inc Coordinator of this site? Confirm its status | Renton | United States | Unknown status |
| National Clin Res Inc. Coordinator of this site? Confirm its status | Richmond | United States | Unknown status |
| Hillcrest Clinical Research Coordinator of this site? Confirm its status | Simpsonville | United States | Unknown status |
| Evanston Premier Hlthcr Res Coordinator of this site? Confirm its status | Skokie | United States | Unknown status |
| Endeavor Health Coordinator of this site? Confirm its status | Skokie | United States | Unknown status |
| Spartanburg Medical Research Coordinator of this site? Confirm its status | Spartanburg | United States | Unknown status |
| New Venture Medical Research Coordinator of this site? Confirm its status | Wadsworth | United States | Unknown status |
| Diablo Clinical Research, Inc. Coordinator of this site? Confirm its status | Walnut Creek | United States | Unknown status |
| Accellacare Coordinator of this site? Confirm its status | Wilmington | United States | Unknown status |
| Selma Medical Associates Coordinator of this site? Confirm its status | Winchester | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.