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NCT06131437CompletedPhase 3

A Research Study to See How Well CagriSema Compared to Tirzepatide Helps People With Obesity Lose Weight

Efficacy and Safety of Cagrilintide 2.4 mg s.c. in Combination With Semaglutide 2.4 mg s.c. (CagriSema s.c. 2.4 mg/2.4 mg) Once-weekly Compared to Tirzepatide 15 mg s.c. Once-weekly in Participants With Obesity

Source: ClinicalTrials.gov · Last updated 6 Feb 2026

Brief summary (registry, in English)

This study will look at how well CagriSema compared to Tirzepatide helps people lower their body weight. CagriSema is a new investigational medicine developed by Novo Nordisk that combines Cagrilintide and Semaglutide. CagriSema is not yet being prescribed by doctors. Participant will get injections once a week throughout the treatment period. Participant will inject the study medicine under the skin with a pen injector in the thigh, stomach, or upper arm. After a first low dose, the study medicine will be gradually increased until reaching the planned dose (2.4 mg CagriSema or 15 mg Tirzepatide). The study will last for about one and a half year for each participant.

Status (registry)
Completed
Phase (registry)
Phase 3
Study type
Interventional
Enrollment
809 (actual)
First submitted
9 Nov 2023
Start date
27 Nov 2023
Primary completion date
8 Dec 2025
Lead sponsor
Novo Nordisk A/S
Diseases
Obesity
NCT number
NCT06131437

What you commit to

  • Study type: Interventional · Phase 3
  • Participants enrolled: 809
  • From 27 Nov 2023 to the primary completion date, 8 Dec 2025
  • 46 sites in 1 country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Other illness

  • History of type 1 or type 2 diabetes mellitus

Lab values

  • Glycated haemoglobin (HbA1c) ≥ 6.5 % (48 millimoles per mole \[mmol/mol\]) as measured by the central laboratory at screening

Who the study is looking for

  • Male or female
  • Age 18 years or above at the time of signing the informed consent
  • Body mass index (BMI) of ≥ 30.0 kilogram per square meter (kg/m\^2)

Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (46)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
Amarillo Med Spec LLP
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AmarilloUnited StatesUnknown status
Washington Cntr Weight Mgmt
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ArlingtonUnited StatesUnknown status
Univ of Colorado at Denver
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AuroraUnited StatesUnknown status
Elligo Clin Res Centre
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AustinUnited StatesUnknown status
UT Health University of Texas
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BellaireUnited StatesUnknown status
Univ of Alabama Birmingham
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BirminghamUnited StatesUnknown status
Holston Medical Group_Bristol
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BristolUnited StatesUnknown status
Northern Pines Hlth Ctr, PC
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BuckleyUnited StatesUnknown status
University of North Carolina
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Chapel HillUnited StatesUnknown status
Medical University of South Carolina
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CharlestonUnited StatesUnknown status
Great Lakes Clinical Trials
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ChicagoUnited StatesUnknown status
StudyMetrix Research, LLC
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City of Saint PetersUnited StatesUnknown status
Hope Clin Res & Wellness
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ConyersUnited StatesUnknown status
FDRC
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Costa MesaUnited StatesUnknown status
Clinical Res Collaborative
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CumberlandUnited StatesUnknown status
Baylr Sctt White Rs Inst, Endo
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DallasUnited StatesUnknown status
UT Southwestern Medical Center-CRU
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DallasUnited StatesUnknown status
Velocity Clin Res, Dallas
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DallasUnited StatesUnknown status
Northeast Research Institute
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Fleming IslandUnited StatesUnknown status
PharmQuest Life Sciences LLC
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GreensboroUnited StatesUnknown status
Medication Mgmnt, LLC_Grnsboro
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GreensboroUnited StatesUnknown status
East West Med Res Inst
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HonoluluUnited StatesUnknown status
Midwest Inst For Clin Res
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IndianapolisUnited StatesUnknown status
Jacksonville Ctr for Clin Res
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JacksonvilleUnited StatesUnknown status
Holston Medical Group.
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KingsportUnited StatesUnknown status
DCOL Ctr for Clin Res
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LongviewUnited StatesUnknown status
South Broward Research LLC
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MiramarUnited StatesUnknown status
Chambliss Clinical Trials, LLC
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MontgomeryUnited StatesUnknown status
Yale University School Of Medicine
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New HavenUnited StatesUnknown status
Health Res of Hampton Roads
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Newport NewsUnited StatesUnknown status
Comprehensive Weight Ctrl Prog
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New YorkUnited StatesUnknown status
Lynn Institute of Norman
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NormanUnited StatesUnknown status
Coastal Carolina Res Ctr
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North CharlestonUnited StatesUnknown status
Capital Clin Res Ctr,LLC
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OlympiaUnited StatesUnknown status
The University of Penn Center
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PhiladelphiaUnited StatesUnknown status
Accellacare_NC
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RaleighUnited StatesUnknown status
Rainier Clin Res Ctr Inc
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RentonUnited StatesUnknown status
National Clin Res Inc.
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RichmondUnited StatesUnknown status
Hillcrest Clinical Research
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SimpsonvilleUnited StatesUnknown status
Evanston Premier Hlthcr Res
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SkokieUnited StatesUnknown status
Endeavor Health
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SkokieUnited StatesUnknown status
Spartanburg Medical Research
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SpartanburgUnited StatesUnknown status
New Venture Medical Research
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WadsworthUnited StatesUnknown status
Diablo Clinical Research, Inc.
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Walnut CreekUnited StatesUnknown status
Accellacare
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WilmingtonUnited StatesUnknown status
Selma Medical Associates
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WinchesterUnited StatesUnknown status

This page is information, not medical advice. Discuss any trial with your doctor.