NCT06133283Completed
Endurance Exercise & Virtual Reality for Optimizing Cortical Excitability and Neuroplasticity in PD
High Intensity Endurance Exercise as a Primer to Virtual Reality for Optimizing Cortical Excitability and Neuroplasticity in Parkinson's Disease (PD)
Source: ClinicalTrials.gov · Last updated 30 Jul 2026
Brief summary (registry, in English)
This study aims to determine the effects of aerobic exercise as a primer to add-on virtual reality (VR)-based rehabilitation on balance, postural control and neuroplasticity (ability of brain to adapt in structure and function) in individuals with Parkinson's disease (PD). This study will utilize two groups - one group will receive the exercise and VR, while the other group will receive stretching exercise and VR over eight weeks. The study team will administer outcomes at baseline, post-intervention (8 weeks) and follow-up (6 weeks after post-assessment).
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 16 (actual)
- First submitted
- 7 Nov 2023
- Start date
- 9 Feb 2024
- Primary completion date
- 11 Nov 2025
- Lead sponsor
- The University of Texas Health Science Center at San Antonio
- Diseases
- Parkinson disease
- NCT number
- NCT06133283
What you commit to
- Study type: Interventional
- Participants enrolled: 16
- From 9 Feb 2024 to the primary completion date, 11 Nov 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Subjects with a history of other neurological diseases (i.e., stroke, multiple sclerosis).
- Subjects with a history of severe cardiopulmonary disease, uncontrolled hypertension, orthostatic hypotension, uncontrolled diabetes, severe osteoporosis, severe arthritis affecting their lower extremity joints.
- Subjects with a history of PD-specific surgical procedures such as deep brain stimulation etc.
- Subjects with a history of head injury.
- Subjects with a history of seizures or epilepsy.
- Individuals who use of medications that could alter corticomotor excitability or increase risk of seizure.
Other
- Subjects who are currently pregnant.
- Individuals with skull abnormalities, fractures or unexplained, recurring headaches.
Who the study is looking for
- Diagnosis of idiopathic PD (ages 18 -85) in Hoehn and Yahr stages 2 - 3.
- Subjects need to demonstrate a score of equal to or greater than 23 on the Mini Mental State Examination.
- Subjects who have a score of ≤21.5 on the Mini Balance Evaluations Systems Test (miniBESTest).
Age in the registry: 18 years to 85 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| UT Health San Antonio- Dept. of Physical Therapy Coordinator of this site? Confirm its status | San Antonio | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.