NCT06140823Active, not recruiting
Prospective Validation of Liver Cancer Risk Computation (LIRIC) Models
Prospective Validation of Liver Cancer Risk Computation (LIRIC) Models on Multicenter EHR Data
Source: ClinicalTrials.gov · Last updated 22 Apr 2026
Brief summary (registry, in English)
The goal of this prospective observational cohort study is to validate previously developed Hepatocellular Carcinoma (HCC) risk prediction algorithms, the Liver Risk Computation (LIRIC) models, which are based on electronic health records. The main questions it aims to answer are: * Will our retrospectively developed general population LIRIC models, developed on routine EHR data, perform similarly when prospectively validated, and reliably and accurately predict HCC in real-time? * What is the average time from model deployment and risk prediction, to the date of HCC development and what is the stage of HCC at diagnosis? The risk model will be deployed on data from individuals eligible for the study. Each individual will be assigned a risk score and tracked over time to assess the model's discriminatory performance and calibration.
- Status (registry)
- Active, not recruiting
- Study type
- Observational
- Enrollment
- 6000000 (actual)
- First submitted
- 15 Nov 2023
- Start date
- 1 Apr 2023
- Primary completion date
- 31 Mar 2027
- Lead sponsor
- Beth Israel Deaconess Medical Center
- Diseases
- Liver and biliary tract cancer
- NCT number
- NCT06140823
What you commit to
- Study type: Observational
- Participants enrolled: 6000000
- From 1 Apr 2023 to the primary completion date, 31 Mar 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Personal history of HCC or current HCC (ICD-9: 155.0; ICD-10: C22.0)
Age
- Age below 40. The same dataset will be utilized for the non-cirrhosis validation, with exclusion of all cases with cirrhosis (ICD-9: 571.2, 571.5; ICD-10: K70, K70.3, K70.30, K70.31, K74, K74.0, K74.6, K74.60, K74.69). For the cirrhosis validation, the investigators will include only patients with the above cirrhosis codes.
Who the study is looking for
- Male and females age ≥40 years from all US HCOs available on the platform
- at least at least 2 clinical encounters to the HCO, within the last year, before the study start date
Criteria the registry did not label
- The investigators will utilize the following criteria for all 3 models:
Age in the registry: 40 years to 100 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Beth Israel Deaconess Medical Center Coordinator of this site? Confirm its status | Boston | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.