NCT06141538Not yet recruiting
Response of Intracardiac Thrombus to Anticoagulants in Patients With Non-valvular Atrial Fibrillation (LYSIS)
Response of Intracardiac Thrombus to Anticoagulants in Patients With Non-valvular Atrial Fibrillation (LYSIS): an Investigator-initiated, National, Multicenter, Retrospective-prospective, Observational Cohort Study
Source: ClinicalTrials.gov · Last updated 4 Apr 2024 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
This study aims to analyze changes in the immune status, metabolic status, and host microbiome community structure in non-valvular atrial fibrillation patients with intracardiac thrombus. Additionally, the study aims to analyze factors that influence the responsiveness and occurrence of adverse events related to anticoagulant therapy.
- Status (registry)
- Not yet recruiting
- Study type
- Observational
- Enrollment
- 500 (estimated)
- First submitted
- 15 Nov 2023
- Start date
- 31 Dec 2024
- Primary completion date
- 31 Jul 2030
- Lead sponsor
- First Affiliated Hospital Xi'an Jiaotong University
- Diseases
- Atrial fibrillation
- NCT number
- NCT06141538
What you commit to
- Study type: Observational
- Planned participants: 500
- From 31 Dec 2024 to the primary completion date, 31 Jul 2030
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Patients with the previous history of hemorrhagic stroke
- Surgery was planned within the intended study time or had been operated within 30 days before the study
- Patients with autoimmune diseases or immunodeficiency, or patients who are currently using immunosuppressants and immunomodulators
Other illness
- Echocardiography confirmed valvular heart disease
- Congenital or acquired coagulation or bleeding disorders
- Other comorbidities that can cause bleeding, such as tumors
Lab values
- Low platelet count or functional platelet defects
- Renal failure (endogenous creatinine clearance \<30ml/min)
Other
- Contraindications to anticoagulants
- Abnormal liver function (liver enzymes \>2 times the upper limit)
- Patients are currently participating in other clinical studies
Who the study is looking for
- Age ≥18 years old, age ≤80 years old
- Patients with atrial fibrillation detected by routine surface 12-lead electrocardiography or Holter
- Transesophageal echocardiography confirmed the presence of cardiac thrombus, and the patient had not received any anticoagulant therapy
Age in the registry: 18 years to 80 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| First Affiliated Hospital of Xian Jiantong University Coordinator of this site? Confirm its status | Xi'an | China | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.