NCT06143488Recruiting
Endovascular Therapy Versus Best Medical Treatment for Acute Large Vessel Occlusion Stroke With Low NIHSS
Source: ClinicalTrials.gov · Last updated 25 Sept 2026
Brief summary (registry, in English)
Patients presenting with mild symptoms of acute ischemic stroke are common and account for approximately half of all acute ischemic stroke. About 30% of patients with minor stroke have a 90-day functional disability. Radiologically proven a large vessel occlusion (LVO) in patients with minor stroke is a well-established predictor of poor outcomes, while the poor outcomes following best medical management in patients with minor stroke with the underlying presence of a LVO are mainly driven by the occurrence of early neurological deterioration (END). Considering the well-known strong association between lack of arterial recanalization and END, endovascular therapy (EVT) appears as an attractive option to improve functional outcomes for LVO-related patients with stroke with mild symptoms. Whether EVT is safe and effective in patients with mild stroke with an LVO is currently debated, since these patients were typically excluded from the pivotal EVT trials. The current study aimed to further test the hypothesis that endovascular therapy would be superior to medical management with respect to functional recovery among low NIHSS patients caused by acute large-vessel occlusion in the anterior circulation.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 264 (estimated)
- First submitted
- 16 Nov 2023
- Start date
- 21 Jan 2024
- Primary completion date
- 31 Dec 2027
- Lead sponsor
- First Affiliated Hospital of Wannan Medical College
- Diseases
- Stroke
- NCT number
- NCT06143488
What you commit to
- Study type: Interventional
- Planned participants: 264
- From 21 Jan 2024 to the primary completion date, 31 Dec 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Criteria the registry did not label
- Aged 18 years or older;
- The time from onset of acute ischemic stroke to randomization is within 24 hours. Onset time is defined as the patient's Last Known Well (LKW);
- Low NIHSS score (2-5 points), with at least one of the following items:
- Altered mental status (lethargy or worse);
- Facial palsy (facial weakness score ≥ 1 point);
- Motor dysfunction (limb weakness score ≥ 1 point);
- Aphasia (language disturbance score ≥ 1 point);
- Hemispatial neglect (neglect score ≥ 1 point);
- Intracranial internal carotid artery, proximal M1 or M2 segment of middle cerebral artery occlusion confirmed by cerebral CTA/MRA/DSA before randomization, which is identified as the culprit vessel for stroke;
- All patients receive CTP/MR perfusion imaging, with a volume of perfusion delay (Tmax\>6 s) ≥ 50 mL;
- Written informed consent is obtained from the patient or legal surrogate, with agreement for long-term follow-up.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| The First Affiliated Hospital, Yijishan Hospital of Wannan Medical College Coordinator of this site? Confirm its status | Wuhu | China | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.