NCT06148051Recruiting
AusCADASIL: An Australian Cohort of CADASIL
Source: ClinicalTrials.gov · Last updated 8 May 2024 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
The aim of this project is to establish an Australian cohort of patients diagnosed with Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL). This study will examine the clinical features and longitudinal course of CADASIL. Outcome measures include neuropsychological profile, neuroimaging, genetics, blood biomarkers, and retinal imaging.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 300 (estimated)
- First submitted
- 7 Nov 2023
- Start date
- 25 Nov 2023
- Primary completion date
- 31 Mar 2027
- Lead sponsor
- Perminder Sachdev
- NCT number
- NCT06148051
What you commit to
- Study type: Observational
- Planned participants: 300
- From 25 Nov 2023 to the primary completion date, 31 Mar 2027
- 5 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- 1\. Significant cognitive impairment leading to an inability to provide informed consent.
Who the study is looking for
- Adults ≥18 years old
- Ability to provide written informed consent
- A large-print version is available for individuals with visual impairment
- An easy-to-read version is available for individuals with cognitive difficulties who may require extra support
- Ability to attend a testing site
- Ability to complete minimum dataset (medical examination and medical history questionnaire, blood test to determine genetic status and a short (20 minute) neuropsychology assessment).
- CADASIL participants according to one of the following categories:
- confirmed diagnosis via genetic testing (NOTCH3 pathogenic variant), OR
- suspected diagnosis based on medical history and brain MRI, OR
- first degree relative of participant who is positive for NOTCH3 pathogenic variant
- OR 6. Unrelated individual who is negative for the NOTCH3 pathogenic variant, and has no cognitive complaints (i.e. control participant)
Age in the registry: 18 years to - · Sex: All · Accepts healthy volunteers
Sites (5)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Royal Brisbane and Women's Hospital Coordinator of this site? Confirm its status | Brisbane | Australia | Not yet recruiting |
| Royal Melbourne Hospital Coordinator of this site? Confirm its status | Melbourne | Australia | Recruiting |
| John Hunter Hospital Coordinator of this site? Confirm its status | Newcastle | Australia | Recruiting |
| University of New South Wales Coordinator of this site? Confirm its status | Sydney | Australia | Recruiting |
| Prince of Wales Hospital Coordinator of this site? Confirm its status | Sydney | Australia | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.