NCT06150560RecruitingPhase 3
A Study of Angiotensin-II Receptor Blocker on Cardiovascular Remodeling (VALUE Trial)
A Phase III, Randomized, Double-Blind, Placebo Controlled Clinical Trial Evaluating the Benefits and Mechanism Of Action Of Angiotensin-II Receptor Blocker On Cardiovascular Remodeling In Patients With Repaired Coarctation Of Aorta
Source: ClinicalTrials.gov · Last updated 11 Sept 2026
Brief summary (registry, in English)
The purpose of this study is to evaluate the effectiveness and mechanism of action of Losartan in the treatment of coarctation of aorta.
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 3
- Study type
- Interventional
- Enrollment
- 120 (estimated)
- First submitted
- 21 Nov 2023
- Start date
- 1 Apr 2024
- Primary completion date
- 1 Jun 2028
- Lead sponsor
- Mayo Clinic
- Diseases
- High blood pressure
- NCT number
- NCT06150560
What you commit to
- Study type: Interventional · Phase 3
- Planned participants: 120
- From 1 Apr 2024 to the primary completion date, 1 Jun 2028
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Currently on beta blocker (BB) therapy
- Received antihypertensive medications within the past year
Lab values
- eGFR\<30
- Hyperkalemia (serum potassium \>5.5mmol/L)
Other
- Pregnancy/lactating
- Severe Aortic or Mitral valve stenosis or regurgitation
- Epicardial CAD diagnosis
Who the study is looking for
- B/S1 hypertension
- SBP 100-139 average based on 3 office measurements.
- Age 18 or Older
- Previous COA Repair
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Mayo Clinic in Rochester Coordinator of this site? Confirm its status | Rochester | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.