NCT06152653Active, not recruitingPhase 4
The Effects of Positive Airway Pressure on the Mucolytic Effects of NAC (TEAM)
The Effects of Positive Airway Pressure on the Mucolytic Effects of NAC
Source: ClinicalTrials.gov · Last updated 13 Aug 2026
Brief summary (registry, in English)
The goal of this clinical trial is to determine if positive pressure during inspiration will improve penetration of aerosolized N-Acetylcysteine (NAC) into airway mucus plugs in the lungs of patients with asthma or Chronic Obstructive Pulmonary Disease (COPD). The main questions it aims to answer are: * Does delivery of aerosolized NAC with positive inspiratory pressure have a greater effect on mucus plug burden in the lungs than delivery of NAC without positive pressure. * Does delivery of aerosolized NAC with positive inspiratory pressure have a greater effect on lung function than delivery of NAC without positive pressure. Participants will be assigned (in a single blind design) to the NAC via jet nebulizer group or the NAC via AeroEclipse-VersaPAP nebulizer group. Participants will each complete 5 treatment visits over the course of 30 days. Each treatment visit will consist of two treatments of a 10% NAC (3 mL) and 2.5 mg albuterol (0.5mL) inhalation solution separated by 4 hours, via the nebulization method specific to their group.
- Status (registry)
- Active, not recruiting
- Phase (registry)
- Phase 4
- Study type
- Interventional
- Enrollment
- 40 (estimated)
- First submitted
- 22 Nov 2023
- Start date
- 9 Apr 2024
- Primary completion date
- Apr 2027
- Lead sponsor
- University of California, San Francisco
- NCT number
- NCT06152653
What you commit to
- Study type: Interventional · Phase 4
- Planned participants: 40
- From 9 Apr 2024 to the primary completion date, Apr 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- A history of medical disease, which in the opinion of the investigator may put the subject at extra risk from study-related procedures or because the disease may influence the results of the study.
Other
- Currently pregnant
- URI in past 10 days
Who the study is looking for
- Asthma Group:
- Male or female between the ages of 18 to 85 at Visit 1
- Written informed consent obtained from subject and ability for subject to comply with the requirements of the study.
- Able to perform reproducible spirometry according to American Thoracic Society (ATS) criteria
- Clinical history of asthma per patient report or medical record
- Asthma requiring treatment with inhaled corticosteroids (ICS) or biologic therapy for 3 months or greater
- Computed Tomography (CT) mucus score ≥ 3 (done as part of screening)
- There is no lower threshold on Forced Expiratory Volume in the first second (FEV1), which means the study will attempt to enroll all patients regardless of asthma severity. However, eligible participants will need to demonstrate ability to tolerate study treatment reflected by a post-treatment FEV1 ≥ 80% of pre- treatment, pre-bronchodilator FEV1. Participants who have a \>20% drop in FEV1 after receiving any study treatment will be excluded from the study.
- For participants with known mucus plugging on CT: no limit on FEV1;
- For participants with unknown mucus plugging: FEV1\<70% predicted
- COPD Group:
- Males or females between the ages 18 to 85 at the time of visit 1.
- Written informed consent obtained from subject and ability for subject to comply with the requirements of the study.
- History of COPD per patient report or medical record and confirmed by an FEV1/FVC ratio of under 70%.
- Current or former smoker with a history of at least 10 pack-years of smoking.
- CT mucus score ≥ 3
- There is no lower threshold on FEV1, which means the study will attempt to enroll all patients regardless of COPD severity. However, eligible participants will need to demonstrate ability to tolerate study treatment reflected by a post-treatment FEV1 ≥ 80% of pre- treatment, pre-bronchodilator FEV1. Participants who have a \>20% drop in FEV1 after receiving any study treatment will be excluded from the study.
- For participants with known mucus plugging on CT: no limit on FEV1; For participants with unknown mucus plugging: FEV1\<50% predicted
Age in the registry: 18 years to 85 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| UCSF Airway Clinical Research Center Coordinator of this site? Confirm its status | San Francisco | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.