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NCT06154265Completed

Intraoperative Echocardiography in Low-Risk CABG Surgery

Default vs As-Needed Intraoperative Transesophageal Echocardiography (TEE) in Low-Risk Isolated Coronary Artery Bypass Graft (CABG) Surgery: A Randomized Controlled Trial

Source: ClinicalTrials.gov · Last updated 12 May 2026

Brief summary (registry, in English)

This goal of this study is to better understand when and where intraoperative transesophageal echocardiography (TEE) should (or should not) be used during coronary artery bypass graft (CABG) surgeries.

Status (registry)
Completed
Study type
Interventional
Enrollment
40 (actual)
First submitted
13 Nov 2023
Start date
22 Jan 2024
Primary completion date
15 Mar 2025
Lead sponsor
University of Pennsylvania
NCT number
NCT06154265

What you commit to

  • Study type: Interventional
  • Participants enrolled: 40
  • From 22 Jan 2024 to the primary completion date, 15 Mar 2025
  • 1 site in 1 country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Prior treatment

  • Any CABG surgery with either "possible" or "definite" aortic intervention listed as a planned part of the procedure. plan for either definite or possible surgical intervention.
  • Any CABG surgery with either "possible" or "definite" valve repair/replacement listed as a planned part of the procedure.
  • Having undergone any previous cardiac surgeries (i.e. scheduled with a "REDO" modifier).
  • Any of these three relative contraindication to TEE:
    • Esophageal varies
    • Gastric bypass surgery
    • Descending thoracic aortic aneurysm

Other illness

  • Documented valve (aortic, mitral, tricuspid, or pulmonic) disease (stenosis or regurgitation) moderate or greater.
  • Proximal/critical left main coronary disease (e.g. greater than or equal to 90% stenosis).
  • Preexisting end-stage renal disease on hemodialysis
  • Preexisting chronic kidney disease (CKD) stage 3, 4, or 5
  • Stroke with residual focal neurological deficit(s) within 90 days of surgery
  • Absolute contraindication to echocardiography defined as one or more of the following documented conditions:
    • Esophagectomy
    • Esophagogastrectomy
    • Esophageal trauma
  • Severe pulmonary hypertension defined as:
    • Pulmonary arterial pressure ≥60 mmHg
    • Pulmonary vascular resistance (PVR) ≥3 Woods Units

Other

  • Preexisting anomalous coronary arteries
  • Any of the following presurgical, mechanical circulatory support devices:
    • Intraaortic balloon pump
    • Percutaneous right ventricular assist device (RVAD)
    • Impella
    • Extracorporeal membrane oxygenation (ECMO)
  • Hemodynamic instability after induction and following placement of an endotracheal tube will be defined as one or more of the following events or scenarios:
    • Placement of an intraaortic balloon pump (IABP)
    • Initiation of venoarterial extracorporeal membrane oxygenation (VAECMO)
    • Placement of a right or left percutaneous mechanical circulatory support device
    • Initiation of epinephrine infusion at a dose ≥ 6 mcg/min for a duration ≥5 minutes
    • Initiation of norepinephrine at a dose ≥8 mcg/min for a duration ≥ minutes
    • Initiation of phenylephrine infusion at a dose ≥100 mcg/min for a duration ≥ minutes
    • Initiation of vasopressin infusion at a dose ≥0.04 units/min for a duration ≥ minutes

Who the study is looking for

  • Scheduled to undergo isolated CABG surgery at a hospital within the UPenn Health System
  • Age ≥18 years
  • Ejection fraction ≥50%
  • Transthoracic echocardiography within one year of scheduled surgery date
  • Left heart catheterization within one year of scheduled surgery date
  • English language fluency or facilitated via language interpreter
  • Able to provide informed consent either in English or via a language interpreter
  • Willing to comply with all study procedures

Age in the registry: 18 years to 100 years · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (1)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
Hospital of the University of Pennsylvania
Coordinator of this site? Confirm its status
PhiladelphiaUnited StatesUnknown status

This page is information, not medical advice. Discuss any trial with your doctor.