NCT06156176Recruiting
Pursuing Reduction in Fatigue After COVID-19 Via Exercise and Rehabilitation (PREFACER): A Randomized Feasibility Trial
Source: ClinicalTrials.gov · Last updated 1 Aug 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
Long COVID is a complex condition that affects approximately 1.4 million Canadians following SARS-CoV-2 infection. Fatigue is the most common symptom of Long COVID. This feasibility trial will evaluate a new rehabilitation program called COVIDEx for treating fatigue after COVID-19, and compare its effectiveness to the standard treatment currently used. The experimental treatment group will receive an 8-week multi-modal rehabilitation program with two 50-minute sessions per week. 60 participants will be recruited, randomly assigned to the COVIDEx program or standard of care (SoC) and followed for 24 weeks.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 60 (estimated)
- First submitted
- 30 Oct 2023
- Start date
- 1 Apr 2025
- Primary completion date
- 1 Apr 2026
- Lead sponsor
- Lawson Research Institute of St. Joseph's
- Diseases
- Long COVID and ME/CFS
- NCT number
- NCT06156176
What you commit to
- Study type: Interventional
- Planned participants: 60
- From 1 Apr 2025 to the primary completion date, 1 Apr 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Received investigational agents as part of a separate study within 30 days of the screening visit
Other illness
- Active SARS-CoV-2 infection
- Pre-existing physical, cognitive, and/or mental health conditions that make exercise contraindicated, consent unattainable, or that cause symptoms similar to those seen in post COVID-19 (e.g., major neurocognitive disorder, schizophrenia, chronic fatigue syndrome) that could affect data
- Has any type of metal bodily implant in head or heart (i.e., pins, plates, pacemakers)
- Current participation in other studies related to COVID-19, exercise, and/or fatigue interventions OR participation within 30 days of the screening visit
Other
- Inability to follow study procedures
- Pregnant and/or breastfeeding
Who the study is looking for
- Adults of at least 18 years of age
- Able to provide informed consent
- Can speak and understand English
- Documented history of SARS-CoV-2 infection (positive PCR/antigen test during acute illness or clinical diagnosis by physician during or after the acute illness)
- Fatigue symptoms within 3 months of COVID-19 infection, lasting at least 2 months
- Fatigue symptoms cannot be explained by an alternative diagnosis
- Fatigue symptoms may be new onset following initial recovery from an acute COVID-19 infection or persist from the initial illness
- Fatigue symptoms may have an episodic nature, fluctuate or relapse over time
- Minimal functional capability: able to walk 10-15 minutes and be recovered within 30-60 minutes or without significant post-exertional malaise (PEM)
- Has applicable technology to access Microsoft Teams and Webex (i.e., computer, laptop, tablet)
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Parkwood Hospital - St. Joseph's Health Care London Coordinator of this site? Confirm its status | London | Canada | Recruiting |
Related publications
This page is information, not medical advice. Discuss any trial with your doctor.