NCT06163534Recruiting
A Longitudinal Multi-Omic Biomarker Profiling Study of Patients With Head & Neck Squamous Cell Carcinoma (HNSCC)
TEMPUS PHOENIX HNSCC STUDY: A Longitudinal Multi-Omic Biomarker Profiling Study of Patients With Head & Neck Squamous Cell Carcinoma (HNSCC)
Source: ClinicalTrials.gov · Last updated 3 Sept 2026
Brief summary (registry, in English)
The study is a prospective, longitudinal, non-interventional, multicenter study of participants with HNSCC who will have tissue and blood based molecular biomarker profiling during their standard of care treatment.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 500 (estimated)
- First submitted
- 7 Nov 2023
- Start date
- 1 Aug 2024
- Primary completion date
- 1 Mar 2028
- Lead sponsor
- Tempus AI
- Diseases
- Head and neck cancer
- NCT number
- NCT06163534
What you commit to
- Study type: Observational
- Planned participants: 500
- From 1 Aug 2024 to the primary completion date, 1 Mar 2028
- 32 sites in 2 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Relapse or recurrence within 6 months of first line chemotherapy and / or chemoradiotherapy
Age
- Clinical evidence of an active second invasive malignancy within \<2 years of enrollment with the exception of stable prostate cancer on watchful waiting, in situ cervical cancer, in situ breast carcinoma or localized non-melanoma skin cancers
Other
- Non-squamous histologies (eg, nasopharynx or salivary gland)
- Tumors that are PD-L1 negative (CPS \<1)
- Unable to comply with study procedures (i.e., not willing or able to have additional blood samples collected)
Who the study is looking for
- ≥18 years of age
- Willing and able to provide informed consent
- Histologically- or cytologically-confirmed metastatic or unresectable, recurrent HNSCC unsuitable for local therapies
- Intended for first line anti-PD1 or PDL1 monotherapy or combination therapy
- Must submit tumor tissue sample representative of current disease per laboratory manual
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (32)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Pan American Cancer for Oncology Coordinator of this site? Confirm its status | San Juan | Puerto Rico | Active, not recruiting |
| ThedaCare Coordinator of this site? Confirm its status | Appleton | United States | Recruiting |
| Winship Cancer Institute, Emory University Coordinator of this site? Confirm its status | Atlanta | United States | Recruiting |
| Morehouse Coordinator of this site? Confirm its status | Atlanta | United States | Recruiting |
| Piedmont Healthcare Coordinator of this site? Confirm its status | Atlanta | United States | Recruiting |
| University of Maryland Coordinator of this site? Confirm its status | Baltimore | United States | Recruiting |
| Dana-Farber Cancer Institute Coordinator of this site? Confirm its status | Boston | United States | Recruiting |
| Northwestern University Feinberg School of Medicine Coordinator of this site? Confirm its status | Chicago | United States | Recruiting |
| University of Cincinnati Coordinator of this site? Confirm its status | Cincinnati | United States | Recruiting |
| Cleveland Clinic Coordinator of this site? Confirm its status | Cleveland | United States | Recruiting |
| Ohio State University Coordinator of this site? Confirm its status | Columbus | United States | Recruiting |
| Cancer Care Specialists of Illinois Coordinator of this site? Confirm its status | Decatur | United States | Recruiting |
| Henry Ford Coordinator of this site? Confirm its status | Detriot | United States | Recruiting |
| Karmanos Cancer Institute Coordinator of this site? Confirm its status | Detroit | United States | Recruiting |
| City of Hope Coordinator of this site? Confirm its status | Duarte | United States | Recruiting |
| Sanford Fargo Coordinator of this site? Confirm its status | Fargo | United States | Recruiting |
| Mayo Clinic Florida Coordinator of this site? Confirm its status | Jacksonville | United States | Recruiting |
| USC / Norris Comprehensive Cancer Center Coordinator of this site? Confirm its status | Los Angeles | United States | Recruiting |
| University of California, Los Angeles Coordinator of this site? Confirm its status | Los Angeles | United States | Recruiting |
| Vanderbilt University Coordinator of this site? Confirm its status | Nashville | United States | Recruiting |
| Mount Sinai Hospital Coordinator of this site? Confirm its status | New York | United States | Recruiting |
| Stanford Coordinator of this site? Confirm its status | Palo Alto | United States | Recruiting |
| Illinois Cancer Care Coordinator of this site? Confirm its status | Peoria | United States | Recruiting |
| University of Pennsylvania Coordinator of this site? Confirm its status | Philadelphia | United States | Recruiting |
| Mayo Clinic - Rochester Coordinator of this site? Confirm its status | Rochester | United States | Recruiting |
| Providence Medical Foundation Coordinator of this site? Confirm its status | Santa Rosa | United States | Recruiting |
| University of Washington Coordinator of this site? Confirm its status | Seattle | United States | Recruiting |
| Sanford Sioux Falls Coordinator of this site? Confirm its status | Sioux Falls | United States | Recruiting |
| Oncology Hematology Associates Coordinator of this site? Confirm its status | Springfield | United States | Recruiting |
| Washington University in St. Louis Coordinator of this site? Confirm its status | St Louis | United States | Recruiting |
| University of Kansas Coordinator of this site? Confirm its status | Westwood | United States | Recruiting |
| Cancer Care Associates of York Coordinator of this site? Confirm its status | York | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.